The best available evidence for the clinical presentation of toxicity is from the Hunter Area Toxicology Service in Australia | Level II* | 1 |
Serotonin toxicity most often happens when 2 serotonin-elevating drugs are used together. The use of an MAOI with an SSRI, an SNRI, or another MAOI is the most concerning drug combination | Level III† | 1,3 |
Some drugs thought to cause serotonin toxicity do not (eg, triptans, ondansetron) | Level III† | 1,4,7–11 |
Prevention of serotonin toxicity through good prescribing practices and monitoring is important | Level III† | 2,12 |