Correction

Recommendations in 2 articles published in Canadian Family Physician, “Nausea and vomiting of pregnancy. Evidence-based treatment algorithm”¹ and “Treatment of nausea and vomiting in pregnancy. An updated algorithm,”² have subsequently come under critical scrutiny.^3,4 These articles were not subjected to standard peer review, and Canadian Family Physician acknowledges that upon closer inspection these articles did not provide satisfactory evidence that would have justified the recommendation of doxylamine-pyridoxine as a sole first-line treatment for nausea and vomiting in pregnancy (NVP). More recent Canadian NVP guidelines have been published⁵; however, a subsequent re-analysis⁶ questions the conclusions of 1 of the studies⁷ cited in these guidelines to justify doxylamine-pyridoxine as a recommended first-line treatment for NVP. Additionally, for the articles in Canadian Family Physician^1,2 there was an undisclosed conflict of interest with Duchesnay, the manufacturer of Diclectin, the combination of doxylamine-pyridoxine. Canadian Family Physician encourages readers to interpret previously published NVP recommendations with caution. Readers are also referred to the commentary “Motherisk and Canadian Family Physician” in the January 2017 issue of Canadian Family Physician.⁸

References

1.↵
1. Levichek Z,
2. Atanackovic G,
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4. Maltepe C,
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7. et al
. Nausea and vomiting of pregnancy. Evidence-based treatment algorithm. Can Fam Physician 2002;48:267-8, 277.
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2.↵
1. Einarson A,
2. Maltepe C,
3. Boskovic R,
4. Koren G
. Treatment of nausea and vomiting in pregnancy. An updated algorithm. Can Fam Physician 2007;53:2109-11.
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3.↵
1. Chin JWS,
2. Gregor S,
3. Persaud N
. Re-analysis of safety data supporting doxylamine use for nausea and vomiting of pregnancy. Am J Perinatol 2014;31(8):701-10. Epub 2013 Dec 9.
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4.↵
1. Persaud N,
2. Chin J,
3. Walker M
. Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy? J Obstet Gynaecol Can 2014;36(4):343-8.
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1. Campbell K,
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. The management of nausea and vomiting of pregnancy. J Obstet Gynaecol Can 2016;38(12):1127-37.
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1. Persaud N,
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. Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: prespecified analyses and reanalysis. PLoS One 2018;13(1):e0189978.
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7.↵
1. Koren G,
2. Clark S,
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6. Umans JG,
7. et al
. Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. Am J Obstet Gynecol 2010;203(6):571.e1-7. Epub 2010 Sep 16.
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8.↵
1. Pimlott N,
2. Kvern B,
3. Woollard R
. Motherisk and Canadian Family Physician. Can Fam Physician 2017;63:13-4. (Eng), e1–2 (Fr).
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