Article Figures & Data
Tables
- Table 1.
Details and results of 2 studies in adults with asthma that examined the effect of quadrupling inhaled corticosteroids as part of an asthma action plan: The Oborne et al study cohort was about 54 y of age and 39% male; the McKeever et al study cohort was about 56 y of age and 33% male.
STUDY GROUP OBORNE ET AL,2 2009 (N = 403) MCKEEVER ET AL,3 2018 (N = 1922) STARTED ORAL CS ADVERSE EVENTS IN THOSE WHO STARTED THE INHALER* SEVERE EXACERBATION† STARTED ORAL CS HOSPITALIZATION FOR ASTHMA THOSE WHO REACHED ZONE 2 OF THEIR SELF-MANAGEMENT PLAN ‡ NONSERIOUS ADVERSE EVENTS ORAL CANDIDIASIS OR DYSPHONIA Placebo or control§ 14% 8% (3 of 38) 52% 40% 1.8% 2% (10 of 552) 1.6% (9 of 552) Quadruple dose 9%‖ 16% (9 of 56) 45% 33% 0.3%¶ 7% (41 of 562) 6.4% (36 of 562) CS—corticosteroids.
↵* 23% of the cohort.
↵† Treatment with oral CS or an unscheduled health care consultation for asthma.
↵‡ 58% of the cohort.
↵§ Placebo group in the study by Oborne et al2 and control group in the study by McKeever et al.3
↵‖ Not statistically different; however, in those patients who actually started the study inhaler there was a statistically significant reduction: 50% (19 of 38) versus 21% (12 of 56).
↵¶ No statistical tests reported.
