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Depression isn't always primary; often secondary to organic disease. Iatrogenic; Industrial toxins; Sex hormone deficiency in both genders; Niacin deficiency; Parathyroid tumour; Post-viral especially Epstein-Barr; and Thyroid disease. In 1940 UK West London Physician Richard ASHER coined MYXOEDEMA MADNESS,(also in 1951, Munchausen's syndrome). He visited Mental Hospitals checking for hypothyroidism; found lots who had been there for decades and with a few thyroid pills walked out; cured.
One of the historical Medical Greats. See extensive references to Dr.R.ASHER in Google.