RT Journal Article SR Electronic T1 Taking ACE inhibitors during pregnancy. Is it safe? JF Canadian Family Physician JO Can Fam Physician FD The College of Family Physicians of Canada SP 1047 OP 1049 VO 48 IS 6 A1 Savithiri Ratnapalan A1 Gideon Koren YR 2002 UL http://www.cfp.ca/content/48/6/1047.abstract AB QUESTION: A pregnant patient is taking enalapril for primary hypertension. How safe are angiotension-converting enzyme inhibitors (ACEI) during pregnancy? ANSWER: Evidence of whether ACEIs cause problems during the first trimester of pregnancy is reassuring. There is evidence that they cause severe renal and other problems during the second and third trimesters, however. These drugs should be avoided during pregnancy.