RT Journal Article SR Electronic T1 Preventing diverticular disease. Review of recent evidence on high-fibre diets. JF Canadian Family Physician JO Can Fam Physician FD The College of Family Physicians of Canada SP 1632 OP 1637 VO 48 IS 10 A1 Aldoori, Walid A1 Ryan-Harshman, Milly YR 2002 UL http://www.cfp.ca/content/48/10/1632.abstract AB OBJECTIVE To review recent evidence on dietary factors associated with diverticular disease (DD) with special emphasis on dietary fibre. QUALITY OF EVIDENCE MEDLINE was searched from January 1966 to December 2001 for articles on the relationship between dietary and other lifestyle factors and DD. Most articles either focused on dietary intervention in treating symptomatic DD or were case-control studies with inherent limitations for studying diet-disease associations. Only one large prospective study of male health professionals in the United States assessed diet at baseline and before initial diagnosis of DD. MAIN MESSAGE A diet high in fibre mainly from fruits and vegetables and low in total fat and red meat decreases risk of DD. Evidence indicates that the insoluble component of fibre is strongly associated with lower risk of DD; this association was particularly strong for cellulose. Caffeine and alcohol do not substantially increase risk of DD, nor does obesity, but higher levels of physical activity seem to reduce risk of DD. CONCLUSION A diet high in fibre and low in total fat and red meat and a lifestyle with more physical activity might help prevent DD.