PT  - JOURNAL ARTICLE
AU  - Shrim, A
AU  - Berger, H
AU  - Kingdom, J
AU  - Hamoudi, A
AU  - Shah, P S
AU  - Koren, G
TI  - Prolonged exposure to angiotensin-converting enzyme inhibitors during pregnancy. Fetal toxicity could be reversible.
DP  - 2005 Oct 01
TA  - Canadian Family Physician
PG  - 1335--1337
VI  - 51
IP  - 10
4099  - http://www.cfp.ca/content/51/10/1335.short
4100  - http://www.cfp.ca/content/51/10/1335.full
SO  - Can Fam Physician2005 Oct 01; 51
AB  - QUESTION: I read in a Motherisk Update that angiotensin-converting enzyme (ACE) inhibitors are contraindicated during pregnancy. Many women, however, do not know they are pregnant for quite some time after conception. One of my patients was taking ACE inhibitors for 3 to 4 months while she was pregnant. How should I advise her? ANSWER: The deleterious effects ACE inhibitors have on fetuses were seen only after exposure during the second and third trimesters and were mostly secondary to renal damage. These effects can be reversed, as described in this Motherisk Update.