TY - JOUR T1 - Use of proton pump inhibitors during pregnancy and breastfeeding. JF - Canadian Family Physician JO - Can Fam Physician SP - 853 LP - 854 VL - 52 IS - 7 AU - Alejandro A Nava-Ocampo AU - Elvia Y Velázquez-Armenta AU - Jung-Yeol Han AU - Gideon Koren Y1 - 2006/07/01 UR - http://www.cfp.ca/content/52/7/853.abstract N2 - QUESTION: A 36-year-old pregnant patient has symptoms of peptic disease. Treatment with diet and lifestyle modifications and also antacids has given her little relief. If she were not pregnant, I would prescribe a proton pump inhibitor (PPI) for her. She is now 4 weeks pregnant, and I need to determine whether PPIs are safe during pregnancy. ANSWER: Data currently available suggest that omeprazole is not teratogenic in humans. While information on other PPIs is limited, a systematic review of the evidence suggests that they are also not teratogenic. ER -