RT Journal Article
SR Electronic
T1 Trastuzumab treatment for breast cancer during pregnancy
JF Canadian Family Physician
JO Can Fam Physician
FD The College of Family Physicians of Canada
SP 31
OP 32
VO 54
IS 1
A1 Alon Shrim
A1 Facundo Garcia-Bournissen
A1 Cynthia Maxwell
A1 Dan Farine
A1 Gideon Koren
YR 2008
UL http://www.cfp.ca/content/54/1/31.abstract
AB QUESTION One of my patients has been diagnosed with breast cancer and started treatment with trastuzumab. She has recently discovered that she is pregnant and wishes to continue the pregnancy. What are the consequences of trastuzumab treatment during pregnancy and can she continue her pregnancy? ANSWER Human data regarding the safety of trastuzumab during pregnancy are scarce. Only 3 case reports could be located in the published literature. Anhydramnios was observed in a case where the exposure to trastuzumab occurred during the second trimester, which reversed after discontinuation of the drug without any apparent consequences to the baby. Evidence is insufficient to provide any recommendations, but in light of the case reports, pregnancies exposed to trastuzumab during the second trimester should be closely followed with particular attention to amniotic fluid volume.