PT  - JOURNAL ARTICLE
AU  - Gill, Simerpal Kaur
AU  - Moretti, Myla
AU  - Koren, Gideon
TI  - Is the use of letrozole to induce ovulation teratogenic?
DP  - 2008 Mar 01
TA  - Canadian Family Physician
PG  - 353--354
VI  - 54
IP  - 3
4099  - http://www.cfp.ca/content/54/3/353.short
4100  - http://www.cfp.ca/content/54/3/353.full
SO  - Can Fam Physician2008 Mar 01; 54
AB  - QUESTION A patient of mine has been prescribed letrozole to induce ovulation; however, a recent release from the Food and Drug Administration contraindicates the use of letrozole in premenopausal women owing to teratogenicity. Does the use of letrozole increase the risk of a child being born with a birth defect? ANSWER The use of letrozole to induce ovulation has not been associated with an increased risk of a child being born with a birth defect; in contrast, the use of clomiphene citrate in pregnancy is associated with intrauterine growth restriction.