RT Journal Article SR Electronic T1 Smoking cessation therapy during pregnancy JF Canadian Family Physician JO Can Fam Physician FD The College of Family Physicians of Canada SP 525 OP 527 VO 58 IS 5 A1 Alex M. Cressman A1 Anna Pupco A1 Eunji Kim A1 Gideon Koren A1 Pina Bozzo YR 2012 UL http://www.cfp.ca/content/58/5/525.abstract AB Question Despite being highly motivated to quit, many of my patients struggle with smoking cessation during pregnancy. Can you comment on the current treatment options and discuss their safety and efficacy during pregnancy? Answer Given the considerable and well-documented adverse effects of antenatal smoking on mother and fetus, pharmacotherapy for smoking cessation should be considered. Available medications include nicotine replacement therapy, sustained-release bupropion, and varenicline. Nicotine replacement therapy and bupropion do not appear to increase the risk of major malformations; however, there is currently limited evidence on the use of varenicline during pregnancy. Given that these agents are only marginally successful in smoking cessation, their use should always be accompanied by behavioural counseling and education to maximize quit rates.