RT Journal Article SR Electronic T1 Approach to lymphogranuloma venereum JF Canadian Family Physician JO Can Fam Physician FD The College of Family Physicians of Canada SP 554 OP 558 VO 62 IS 7 A1 Patrick O’Byrne A1 Paul MacPherson A1 Stephane DeLaplante A1 Gila Metz A1 Andree Bourgault YR 2016 UL http://www.cfp.ca/content/62/7/554.abstract AB Objective To review the literature about lymphogranuloma venereum (LGV) and to provide an overview and discussion of practice guidelines.Sources of information The terms Chlamydia trachomatis and lymphogranuloma venereum were searched separately in PubMed. Empirical studies, practice reviews, and clinical guidelines were included. All reference lists were reviewed for additional articles.Main message Since 2003, there has been a resurgence of LGV among men who have sex with men in many Western countries, including Canada. Although LGV is a serovar of Chlamydia trachomatis (serovar L), it can invade regional lymph nodes, and consequently presents with different symptoms than the other subtypes of chlamydia (serovars A through K). Specifically, LGV transitions through 3 phases: a painless papule or ulcer at the site of inoculation; invasion of the regional lymph nodes, which can present with an inguinal or rectal syndrome; and irreversible destruction of lymph tissue. In contrast, chlamydia serovars A to K exclusively produce superficial mucosal infections. Lymphogranuloma venereum also requires a different treatment regimen than other chlamydia serovars.Conclusion In light of the current resurgence of LGV, its unique symptoms and clinical course, and its requirement for a different treatment than other chlamydia serovars, it is important for primary care providers to recognize when LGV should be included as an appropriate differential diagnosis.