TY - JOUR T1 - Henoch-Schönlein purpura in children JF - Canadian Family Physician JO - Can Fam Physician SP - 895 LP - 897 DO - 10.46747/cfp.6612895 VL - 66 IS - 12 AU - Amir Gohari AU - Douglas G. Matsell AU - Cherry Mammen AU - Ran D. Goldman Y1 - 2020/12/01 UR - http://www.cfp.ca/content/66/12/895.abstract N2 - Question A few patients have previously presented to my clinic with palpable purpura, joint inflammation, and severe abdominal pain characteristic of Henoch-Schönlein purpura (HSP). Considering that renal injury is the primary long-term complication of HSP, are corticosteroids effective in preventing or treating renal disease in children with HSP?Answer Henoch-Schönlein purpura is self-limiting in 94% of children, but permanent renal injury is reported in one-fifth of children with nephritic or nephrotic features. Corticosteroids have been considered as candidates for preventing and treating renal involvement in HSP. There is a moderate level of evidence to suggest corticosteroids are not effective in preventing renal involvement in HSP. However, based on low-level evidence and similarities with primary immunoglobulin A nephropathy, experts recommend corticosteroids in treating renal involvement in HSP to prevent long-term kidney injury. Dose and duration of therapy should be carefully considered in consultation with a pediatric nephrologist. ER -