Table 1

Effects of 5-HT receptor subtypes in relation to serotonin toxicity

5-HT RECEPTORMAIN ACT ION RELATED TO SEROTONIN TOXICITY
5-HT1ANeuronal inhibition, regulation of sleep, feeding, thermoregulation, hyperactivity associated with anxiety, hypoactivity associated with depression
5-HT1DLocomotion, muscle tone
5-HT2ANeuronal excitation, learning, peripheral vasoconstriction, platelet aggregation
5-HT2BStomach contraction
5-HT3Nausea and vomiting, anxiety
5-HT4Gastrointestinal motility

  • 5-HT—serotonin.

  • Data from Boyer and Shannon.4