Symptoms of milk protein allergy and their differential diagnoses
| REACTION TYPE | PRESENT ATION | DIFFERENTIAL DIAGNOSES TO CONSIDER |
|---|---|---|
| igE mediated | ||
| Respiratory | Rhinoconjunctivitis
Asthma (wheeze, cough) Laryngeal edema Otitis media with effusion | Primary respiratory problem |
| Cutaneous | Atopic dermatitis
Urticaria Angioedema | Food allergy
Environmental allergy Primary atopy |
| Gastrointestinal | Oral allergy syndrome
Nausea and vomiting Colic Diarrhea | Food or environmental allergy
Infection, delayed gastric emptying, malrotation, celiac disease (younger than 6 mo), cystic fibrosis |
| Non–Ige mediated | ||
| Respiratory | Pulmonary hemosiderosis (Heiner syndrome) | None |
| Cutaneous | Contact rash
Atopic dermatitis | Food or environmental allergy
Primary atopy |
| Gastrointestinal | Gastroesophageal reflux
Transient enteropathy Protein-losing enteropathy Enterocolitis syndrome Colitis Constipation Failure to thrive | Physiologic reflux, delayed
gastric emptying, celiac disease (younger than 6 mo), cystic fibrosis Anal fissure Hypercalcemia, Hirschsprung disease, hypothyroidism, functional gastrointestinal disorders |
| Other | ||
| Unclassified (rare) | Anemia (without colitis)
Arthritis Henoch-Schönlein purpura Migraine | Broad |