Table 2

Signs and symptoms of metastatic breast cancer

SITE OF SPREADSYMPTOMSIGN
Lymph nodesPain and swelling in axillary, supraclavicular, or infraclavicular areasAxillary, supraclavicular, or infraclavicular adenopathy
BonePain in bones out of keeping with patients’ usual pain, without previous trauma and not responding to medicationTenderness on percussion of the spine
LiverAbdominal pain, early satietyEnlarged liver on palpation, with a firm liver edge
LungShortness of breathAuscultation and percussion of lungs compatible with pleural effusion or pulmonary edema
BrainMorning headache, vomitingNeurologic symptoms, papilledema