Table 2.

HIV preexposure prophylaxis recommendations

STEPAPPROACH
Assessments at baseline

  • History and examination: signs and symptoms of HIV seroconversion and medication use

  • Blood tests: HIV, syphilis, hepatitis B virus (and hepatitis C virus, as indicated), β-hCG levels (when indicated), creatinine level

  • Urine NAAT: gonorrhea, chlamydia

  • Extragenital NAAT: oropharynx, rectum

Assessments at 1 moHIV test, creatinine level
Initial prescription18

  • 200 mg of emtricitabine and 300 mg of tenofovir disoproxil fumarate taken orally daily for 30 d (for males, females, transgender individuals)

Or:

  • 200 mg of emtricitabine and 25 mg of tenofovir alafenamide fumarate taken orally daily for 30 d (for MSM only)

Monitoring every
3 mo

  • History and examination: signs and symptoms of HIV seroconversion and medication use

  • Blood: HIV test, syphilis test, creatinine level

  • Urine NAAT: gonorrhea, chlamydia

  • Extragenital NAAT: oropharynx, rectum

Ongoing prescription18

  • 200 mg of emtricitabine and 300 mg of tenofovir disoproxil fumarate taken orally daily for 90 d (for males, females, transgender individuals)

Or:

  • 200 mg of emtricitabine and 25 mg of tenofovir alafenamide fumarate taken orally daily for 90 d (for MSM only)

  • hCG—human chorionic gonadotropin, MSM—men who have sex with men, NAAT—nucleic acid amplification test.