Table 1.

Randomized trial results of adjunctive folate treatment in major depressive disorder: A 10-week trial measuring the effect of folate when combined with fluoxetine.

TREATMENTMEAN HDRS AT END OF STUDY*RESPONSE RATE,* %REMISSION RATE,* %
MEN (N = 40)WOMEN (N = 69)MEN (N = 40)WOMEN (N = 69)MEN (N = 40)WOMEN (N = 69)
Folate12.36.861.193.95072.7
Placebo10.511.763.661.15047.2
Difference+1.8−4.9−2.5+32.8025.5
P valueNS< .001NS< .005NS< .06
  • HDRS—Hamilton Depression Rating Scale, NS—not significant.

  • * Per protocol analysis comparing fluoxetine and folate with fluoxetine alone (intention-to-treat subanalysis not provided); study dropout rate was 14%.

  • Response: > 50% reduction in HDRS; remission: HDRS final score ≤ 9. Data from Coppen and Bailey.2