Table 2.

Randomized trial results of adjunctive folate treatment in major depressive disorder: A 52-week trial measuring the effect of folate augmentation in lithium clinic patients with unipolar depression.

TREATMENTMEAN BDI AT START OF STUDY (N = 53)BDI AT END OF STUDY (N = 53)PVALUE
Folate7.46.3< .02*
Placebo8.79.2NS*
  • BDI—Beck Depression Inventory, NS—not significant.

  • * Baseline to end point within group comparison (between group comparison not provided).

  • Data from Coppen et al.5