Frederickson classification of familial hyperlipidemia
| TYPE OF HYPERLIPIDEMIA | CONDITION | TYPE OF XANTHOMAS | TRIGLYCERIDE LEVELS | CHOLESTEROL LEVELS | ELEVATED LIPOPROTEIN |
|---|---|---|---|---|---|
| I | Familial chylomicronemia | Eruptive | Very highly elevated | Slightly elevated | Chylomicrons |
| IIa | Familial hypercholesterolemia; familial defective apolipoprotein B | Tendinous, tuberous, planar | Normal | Highly elevated | LDL |
| IIb | Familial combined hyperlipidemia | None | Elevated | Elevated | LDL and VLDL |
| III | Familial dysbetalipoproteinemia | Planar, tuberous, tuberoeruptive | Highly elevated | Elevated | Chylomicron and VLDL remnants |
| IV | Familial hypertriglyceridemia | Eruptive (rare) | Elevated | Normal | VLDL |
| V | Mixed hyperlipidemia | Eruptive | Very highly elevated | Elevated | Chylomicrons and VLDL |
LDL—low-density lipoprotein, VLDL—very low–density lipoprotein.
Data from Rader and Hobbs4 and Fredrickson and Lees.5