GROUPS | FAMILY HISTORY TESTING CRITERIA* | NO. OF PATIENTS WHO WOULD HAVE QUALIFIED FOR TESTING BEFORE DIAGNOSIS (TOTAL = 41) | POSITIVITY RATE IN LRCP DATABASE, FOR ALL TESTED PROBANDS, 1997–2008† (N = 1270), % |
---|---|---|---|
Group 1 | Ashkenazi Jewish AND breast cancer at age < 50 y OR ovarian cancer at any age | 0 | 0.0 |
Group 2 | Breast cancer at age < 35 y | 4 | 7.7 |
Group 3 | Male breast cancer at any age | 0 | 0.0 |
Group 4 | Invasive serous ovarian cancer at any age | 0 | 8.5 |
Group 5 | Breast cancer at age < 60 y AND first- or second-degree relative with ovarian cancer OR male breast cancer at any age | 4 | 13.3 |
Group 6 | Breast and ovarian cancer in same individual OR bilateral breast cancer with first case at age < 50 y | 9 | 15.4 |
Group 7 | Two cases of breast cancer in first- or second-degree relatives at age < 50 y | 4 | 15.1 |
Group 8 | Two cases of ovarian cancer, at any age, in first- or second-degree relatives | 0 | 15.8 |
Group 9 | Ashkenazi Jewish with breast cancer at any age and family history of breast or ovarian cancer | 0 | 11.8 |
Group 10 | Three or more cases of breast or ovarian cancer | 24 | 12.3 |
LRCP—London Regional Cancer Program.
↵* Data from the Predictive Cancer Genetics Steering Committee, 2001.28
↵† Positivity rate data are LRCP internal data for probands tested between 1997 and 2008. A proband is an individual being studied or reported on. A proband is usually the first affected individual in a family who brings a genetic disorder to the attention of the medical community.35