Table 1

Patient characteristics

CASEAGE, SEX, AND ETHNICITYGIS, DURATION OF DISEASE, AND ASSOCIATED DISEASESCLINICAL FEATURES AND DIFFERENTIAL DIAGNOSISANTI-tTG LEVELS, TITRE, AND G6PD BLOOD LEVELS*HISTOLOGIC ASPECTS AND DIRECT IMMUNOFLUORESCENCE RESULTSTREATMENT AND FOLLOW-UP
Patient 144 y
Male
White		No
1 y
Hypothyroidism

  • Pruritus and prurigo-like papule vesicles and petechiae on the elbows

  • Bullous pemphigoid

  • 196.8 U/mL (ELISA; normal level below 20 U/mL)

  • 1:160

  • 44.9 mU/billion red blood cells

  • Subepidermal bullae containing numerous neutrophils and neutrophilic microabscesses at the papillary dermal tips

  • Granular IgA deposits on the upper dermis

  • Gluten-free diet and tetracycline 2 g/d plus oral nicotinamide 1.5 g/d

  • Improvement after 2 wk

Patient 219 y
Female
White		No
1.5 y
None

  • Severe itching all over the body and excoriated papules and hematic crusts on the extensor surfaces of the forearms, elbows, and legs; lumbar area; intergluteal region; scalp; and submandibular skin

  • Scabies

  • 90 U/mL (normal level below 35 U/mL)

  • Not done

  • Normal

  • Subepidermal bullae with neutrophilic infiltrate

  • Granular IgA deposition on the upper dermis

  • Oral dapsone 100 mg/d

  • Free of itch after 4 d

Patient 358 y
Male
White		Yes
10 y
Hypothyroidism

  • Itching and excoriated papules on extensor surfaces of the limbs, lumbar area, and buttocks

  • Scabies and atopic dermatitis

  • 175 U/mL (normal level below 35 U/mL)

  • Not done

  • Normal

  • Subepidermal cleavage with neutrophilic infiltrate and microabscess on the papillary dermis

  • Granular IgA deposition on subepidermal area

  • Gluten-free diet for 4 mo

  • After 6 mo, free of lesions and gained 3.6 kg

Patient 422 y
Male
White		No
1.5 y
Hypothyroidism

  • Numerous excoriated papules and crusts distributed on the dorsum of the hands, scalp, neck, extensor surfaces of the limbs, lumbar area, and intergluteal region; and several new and old petechial lesions at the volar aspect of the hands and feet

  • Scabies

  • 18 U/mL (ELISA; normal level below 10 U/mL)

  • Not done

  • Normal

  • Subepidermal vesicle with neutrophilic infiltrate

  • Granular IgA deposits on the upper dermis

  • Oral dapsone 100 mg/d

  • Not reported

  • ELISA—enzyme-linked immunosorbent assay, G6PD—glucose-6-phosphate dehydrogenase, GIS—gastrointestinal symptoms, Ig—immunoglobulin, tTG—tissue transglutaminase.

  • ↵* A normal G6PD level is greater than 118.0 mU/billion red blood cells.