Patient’s metoprolol and α-hydroxymetoprolol serum concentrations; metoprolol–α-hydroxymetoprolol metabolic ratio; heart rate; and blood pressure before metoprolol intake and 1 or 3 hours after metoprolol intake, with and without propafenone
| METOPROLOL DAILY DOSE | METOPROLOL SERUM LEVEL (μg/L) | α-HYDROXYMETOPROLOL SERUM LEVEL (μg/L) | METOPROLOL–α-HYDROXYMETOPROLOL METABOLIC RATIO | HEART RATE (BEATS/MIN) | BLOOD PRESSURE (mm Hg) |
|---|---|---|---|---|---|
| 200 mg with propafenone | |||||
| • Before metoprolol intake | 152.4 | 4.4 | 34.6 | 66 | 136/76 |
| • 1 h after | 333.2 | 3.8 | 87.7 | 59 | 134/72 |
| • 3 h after | 412.2 | 4.0 | 104.3 | 61 | 128/76 |
| 100 mg with propafenone | |||||
| • Before metoprolol intake | 79.2 | 7.7 | 10.3 | 68 | 132/68 |
| • 1 h after | 168.6 | 4.0 | 42.2 | 67 | 138/74 |
| 100 mg without propafenone | |||||
| • Before metoprolol intake | 10.3 | 32.0 | 0.3 | 55 | 124/62 |
| • 1 h after | 53.8 | 44.0 | 1.2 | 62 | 126/70 |
| • 3 h after | 134.9 | 97.7 | 1.4 | 53 | NA |
NA—not available.