Methadone dosing
| METHADONE DOSING | SITE | TOTAL COHORT (N = 102) | P VALUE | ||
|---|---|---|---|---|---|
| TORONTO (N = 44) | VANCOUVER (N = 36) | MONTREAL (N = 22) | |||
| Taking methadone at conception, n (%) | 25 (57) | 12 (33) | 16 (73) | 53 (52) | .010* |
| Mean (SD) gestational age at methadone initiation, wk | 2.4 (8.9) | 19.9 (7.9) | 18.3 (9.6) | 20.7 (8.4) | .506 |
| Mean (SD) methadone dose, mg | |||||
| • Before pregnancy | 60.3 (51.4) | 62.6 (34.3) | 84.8 (26.9) | 67.6 (42.8) | .208 |
| • End of first trimester | 59.2 (45.3) | 64.3 (30.8) | 74.1 (35.1) | 64.6 (39.0) | .448 |
| • End of second trimester | 66.9 (47.0) | 73.2 (38.3) | 87.9 (36.0) | 74.0 (42.0) | .202 |
| • At delivery | 73.5 (49.6) | 85.7 (41.2) | 93.9 (41.8) | 82.4 (45.3) | .202 |
| • Postpartum (up to 6 wk) | 74.6 (49.1) | 79.0 (41.0) | 93.3 (41.2) | 80.6 (44.5) | .288 |
| Split dose, n (%) | 10 (23) | 18 (50) | 7 (32) | 35 (34) | .027* |
↵* Indicates significant difference at P < .05.