Table 1.

Characteristics of included systematic reviews

SYSTEMATIC REVIEW	CORE TOPIC	SUBGROUP	NO. OF RCTS	NO. OF PATIENTS	META-ANALYSES	*MODIFIED AMSTAR^ SCORE**
Whiting et al, 2015²	Pain	Chronic pain	28	2454	Yes	6
	Spasticity	Spasticity (due to MS or paraplegia)	14	2280	Yes
	Nausea and vomiting	Chemotherapy	28	1772	Yes
	Adverse events	Any	62	NR	Yes
Martin-Sanchez et al, 2009¹⁴	Pain	Chronic pain	18	809	Yes	5
Martin-Sanchez et al, 2009¹⁴	Adverse events	Chronic pain	6	540	Yes
Andreae et al, 2015¹⁵	Pain	Neuropathic pain	5	178	Yes	6
Petzke et al, 2016¹⁶	Pain	Neuropathic pain	15	1619	Yes	5
Petzke et al, 2016¹⁶	Adverse events	Neuropathic pain	11	1574	Yes
Lobos Urbina and Peña Duran, 2016¹⁷	Pain	Cancer pain	6	NR	Yes	1
Lobos Urbina and Peña Duran, 2016¹⁷	Adverse events	Cancer	NR	NR	Yes
Iskedjian et al, 2007¹⁸	Pain	MS pain	7	298	Yes	6
Iskedjian et al, 2007¹⁸	Adverse events	MS	7	298	Yes
Mücke et al, 2016¹⁹	Pain	Palliative care pain	2	537	Yes	6
	Nausea and vomiting	Palliative care nausea and vomiting	5	635	Yes
	Adverse events	Palliative care	6	1031	Yes
Fitzcharles et al, 2016²⁰	Pain	Rheumatologic	4	160	No	5
Fitzcharles et al, 2016²¹	Pain	Rheumatologic	4	203	No	4
Walitt et al, 2016²²	Pain	Fibromyalgia	2	72	No	5
Stevens and Higgins, 2017²³	Pain	Acute pain	7	611	No	5
Tateo, 2017²⁴	Pain	Cancer pain	8	683	No	3
Smith et al, 2015²⁵	Nausea and vomiting	Chemotherapy	23	1326	Yes	6
Smith et al, 2015²⁵	Adverse events	Chemotherapy	11	1055	Yes
Machado Rocha et al, 2008²⁶	Nausea and vomiting	Chemotherapy	30	1719	Yes	5
Tramèr et al, 2001²⁷	Nausea and vomiting	Chemotherapy	30	1760	Yes	2
Tramèr et al, 2001²⁷	Adverse events	Chemotherapy	19	1111	Yes
Wade et al, 2010²⁸	Spasticity	MS spasticity	3	666	Yes	2
Wade et al, 2010²⁸	Adverse events	MS	3	666	Yes
Meza et al, 2017²⁹	Pain	MS pain	3	327	No	1
	Spasticity	MS spasticity	4	1247	No
	Adverse events	MS	4	1025	No
Wang et al, 2008³⁰	Adverse events	Any	23	2068	Yes	5
Koppel et al, 2014³¹	Spasticity	MS spasticity	17	NR	No	4
Koppel et al, 2014³¹	Adverse events	MS	24	2737	Yes
Boychuk et al, 2015³²	Pain	Neuropathic pain	13	771	No	4
CADTH, 2010³³	Pain	Chronic noncancer pain	3	265	No	1
CADTH, 2010³⁴	Pain	Neuropathic pain	7	444	No	0
CADTH, 2011³⁵	Pain	Nabilone for chronic pain	2	44	No	2
Campbell et al, 2001³⁶	Pain	Various	9	222	No	5
Cotter, 2009³⁷	Nausea and vomiting	Chemotherapy	9	885	No	3
Deshpande et al, 2015³⁸	Pain	Chronic noncancer pain	6	226	No	5
Jensen et al, 2015³⁹	Pain	Various	22	1227	No	1
Lakhan and Rowland, 2009⁴⁰	Spasticity	MS spasticity	6	481	No	5
Lynch and Campbell, 2011⁴¹	Pain	Chronic noncancer pain	18	766	No	4
Lynch and Ware, 2015⁴²	Pain	Chronic noncancer pain	11	1185	No	4
Tsang and Giudice, 2016⁴³	Pain	Nabilone for pain	7	251	No	2

CADTH—Canadian Agency for Drugs and Technologies in Health, MS—multiple sclerosis, NR—not reported, RCT—randomized controlled trial.
↵* Possible scores range from 0 to 6, with higher scores representing lower risk of bias.