Microdosing regimen used with Ms Z.
| DAY | ADMINISTERED REGIMEN OF BUPRENORPHINE-NALOXONE |
|---|---|
| 1 | 0.5 mg and 0.125 mg SL once daily |
| 2 | 0.5 mg and 0.125 mg SL once daily |
| 3 | 1 mg and 0.25 mg SL once daily |
| 4 | 1.5 mg and 0.375 mg SL once daily |
| 5 | 2 mg and 0.5 mg SL once daily |
| 6 | 2 mg and 0.5 mg SL once daily |
| 7 | 3 mg and 0.75 mg SL once daily plus 2 mg and 0.5 mg SL as needed twice daily Discontinue fentanyl patch |
| 8 | 8 mg and 2 mg SL once daily plus 2 mg and 0.5 mg SL as needed twice daily |
| 9 | 12 mg and 3 mg SL once daily* |
SL—sublingual.
* Over the next 2 weeks, Ms Z.’s dosage was titrated to a total of 24 mg and 6 mg, based on her symptoms.