Table 1.

Head-to-head overall hypoglycemia rates among basal insulins

COMPARATOROVERALL HYPOGLYCEMIA RESULTS
CADTH meta-analysis21

  • NPH: 55.9%

  • Glargine: 47.2%

  • NNT = 12 over 6-12 mo

EDITION meta-analysis24

  • 100 units/mL glargine: 72.8%

  • 300 units/mL glargine: 66.5%

  • NNT = 16 over 6 mo

SWITCH 2 trial25

  • 100 units/mL glargine: 31.6%

  • Degludec: 22%

  • NNT = 11 over 7 mo

  • CADTH—Canadian Agency for Drugs and Technologies in Health, NNT—number needed to treat, NPH—neutral protamine Hagedorn.