Table 1.

Overview of the DIMS-PLUS5 framework

DELIRIUM TRIGGERSASSESS FOR …
DrugIntoxication or overdose, withdrawal, or deliriogenic side effects due to the following: alcohol, cannabinoids, recreational drugs, sedatives or benzodiazepines, anesthetics, anticholinergics or antihistaminergics (eg, dimenhydrinate, diphenhydramine, antispasmodics, muscle relaxants), antidepressants, antipsychotics, anticonvulsants, narcotics (including those causing opioid-induced neurotoxicity), steroids, dopaminergics (eg, levodopa and carbidopa combination), digoxin, lithium, and drugs containing heavy metals or toxins
InfectionBodily infection, such as respiratory infection, urinary tract infection, cellulitis, and bacteremia
MetabolicMetabolic triggers such as hypoxia, hypercarbia, hyperglycemia, hypoglycemia, hematologic abnormalities (eg, anemia, hypereosinophilia), electrolyte abnormalities (eg, sodium, calcium, magnesium, phosphate), renal failure, hepatic failure, thyroid or pituitary or adrenal dysfunction, and acid-base abnormalities
Structural and systemsNeurologic factors (eg, stroke, encephalitis or encephalopathy, intracranial hemorrhage, tumour, head injury, seizure or nonconvulsive status epilepticus), cardiopulmonary factors (eg, shock, hypertensive crisis, respiratory failure, acute coronary syndrome, arrhythmia, heart failure, pulmonary embolism), and any other acute medical or surgical event
PainPoorly controlled pain
Liquids and solidsDehydration and malnutrition, including macronutrient and micronutrient deficiencies (eg, thiamine and vitamin B12) and restrictive diets
Urine and bowelsUrinary retention and constipation
SensesUncorrected vision, hearing, or communication deficits
SleepPoor sleep habits (eg, disrupted sleep, napping)
SettingDisruptive or unfamiliar environment, lack of orientation devices, absence of natural day-night cues, social isolation, or lack of family presence
StasisRestraints (including immobilizing equipment such as intravenous lines, indwelling urinary catheters, tubes, drains) or deconditioning
StressPsychological distress