Summary
To assess physician preferences in the diagnosis and treatment of Lyme disease, questionnaires were sent to physicians in various Lyme disease endemic areas in the U. S. Seventy-eight responses were analyzed. Both ELISA and Western blot were ordered by 86% of responders. Fifty percent of responders believed that 25% or more of patients who have Lyme disease were seronegative. The treatment was influenced by physician specialty. Antibiotic treatment for tick bite was prescribed by 20% of responders. Erythema migrans rash was treated by all responders without serologic confirmation. The median treatment duration of erythema migrans was 4 weeks. For post-erythema migrans Lyme disease, 43% of responders treat 3 months or more; for chronic Lyme disease, 57% of responders treat 3 months or more. Our survey documents significant differences between published recommendations and actual practices. Physician education and clinical trials are needed to clarify the reasons for these differences.
Zusammenfassung
Zur Erhebung von Daten zur Präferenz amerikanischer Ärzte in der Diagnostik und Therapie der Lyme-Borreliose wurden in verschiedenen endemischen Gebieten der USA Fragebogen an Ärzte verschickt. 78 Antworten wurden ausgewertet. 86% der Befragten forderten eine Untersuchung mittels ELISA und Western Blot. 50% der Befragten gaben an, daß ihrer Ansicht nach 25% der Patienten mit Lyme-Borreliose seronegativ sind. In der Therapiewahl ist ein Einfluß der Spezialisierung der Ärzte zu erkennen. 20% der Befragten verordnen nach Zeckenstich ein Antibiotikum. Alle Ärzte gaben an, das Erythema migrans auch ohne serologische Bestätigung mit Antibiotika zu behandeln. Die mediane Behandlungsdauer bei Erythema migrans betrug 4 Wochen. Eine nach Erythema migrans auftretende Lyme Borreliose wurde von 43% der Befragten 3 Monate oder länger behandelt. Die von uns durchgeführte Umfrage deckte erhebliche Unterschiede zwischen publizierten Empfehlungen und der Praxis auf. Es ist erforderlich, die Gründe für diese Unterschiede aufzuklären und den Ärzten Fortbildung anzubieten.
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References
Burgdorfer, W., Barbour, A. G., Hayes, S. F., Benach, J. L., Grunwaldt, E., Davis, J. P. Lyme disease — a tick-borne spirochetosis? Science 216 (1982) 1317–1319.
MMWR 43 (1995) 963.
Bakken, L. L., Case, K. L., Callister, S. M., Bourdeau, M. J., Schell, R. F. Performance of 45 laboratories participating in a proficiency testing program for Lyme disease serology. JAMA 268 (1992) 891–895.
Dattwyler, R. J., Volkman, D. J., Luft, B. J., Halperin, J. J., Thomas, J., Golightly, M. G. Seronegative Lyme disease: dissociation of specific T- and B-lymphocyte responses toBorrelia burgdorferi. N. Engl. J. Med. 319 (1988) 1441–1446.
Schutzer, S. E., Coyle, P. K., Belman, A. L., Golightly, M. G., Drulle, J. Sequestration of antibody toBorrelia burgdorferi in immune complexes in seronegative Lyme disease. Lancet 335 (1990) 312–315.
Steere, A. C., Taylor, E., McHugh, G. L., Logigian, E. L. The over-diagnosis of Lyme disease. JAMA 269 (1993) 1812–1816.
Sigal, L. H. Summary of the first 100 patients seen at a Lyme disease referral center. Am. J. Med. 88 (1990) 577–581.
Eppes, S. C., Klein, J. D., Caputo, G. M., Rose, C. D. Physician beliefs, attitudes, and approaches toward Lyme disease in an endemic area. Clin. Pediatr. (Phila.) 33 (1994) 130–134.
Jung, P. I., Nahas, J. N., Strickland, G. T., McCarter, R., Israel, E. Maryland physicians' survey on Lyme disease. Md. Med. J. 43 (1994) 447–450.
Strickland, G. T., Caisley, I., Woubeshet, M., Israel, E. Antibiotic therapy for Lyme disease in Maryland. Public Health Rep. 109 (1994) 745–749.
Steere, A. C., Malawista, S. E., Snydman, D. R., Shope, R. E., Andiman, W. A., Ross, M. R., Steele, F. M. Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three Connecticut communities. Arthritis Rheum. 20 (1977) 7–17.
Duray, P. H. Clinical pathologic correlations of Lyme disease. Rev. Infect. Dis. 11 (Suppl. 6) (1989) S 1487–1493.
Kantor, F. S. Disarming Lyme disease. Sci. Am. 271 (1994) 34–39.
National Institutes of Health Diagnosis and treatment of Lyme disease. Clinical Courier 9 (1991) 1–8.
Corpuz, M., Hilton, E., Lardis, M. P., Singer, C., Zolan, J. Problems in the use of serologic tests for the diagnosis of Lyme disease. Arch. Intern. Med. 151 (1991) 1837–1840.
Tilton, R. C. Laboratory aids for the diagnosis ofBorrelia burgdorferi infection. J. Spirochetal Tick-Borne Dis. 1 (1994) 18–23.
Luger, S. W., Kraus, E. Serologic tests of Lyme disease: interlaboratory variability. Arch. Intern. Med. 150 (1990) 761–763.
Schwartz, B. S., Goldstein, M. D., Ribeiro, J. M., Schulze, T. L., Shahield, S. I. Antibody testing in Lyme disease: a comparison of results in four laboratories. JAMA 262 (1992) 3431–3434.
Berger, B. W. Cutaneous manifestations of Lyme borreliosis. Rheum. Dis. Clin. North Am. 15 (1989) 627–634.
Shadick, N. A., Phillips, C. B., Logigian, E. L., Steere, A. C., Kaplan, R. F., Berardi, V. P., Duray, P. H., Larson, M. G., Wright, E. A., Ginsburg, K. S., Katz, J. N., Liang, M. H. The long-term clinical outcomes of Lyme disease. A population-based retrospective cohort study. Ann. Intern. Med. 121 (1994) 560–567.
Asch, E. S., Bujak, D. I., Weiss, M., Peterson, M. G., Weinstein, A. Lyme disease: an infectious and postinfectious syndrome. J. Rheumatol. 21 (1994) 454–461.
Liegner, K. B. Lyme disease: the sensible pursuit of answers. J. Clin. Microbiol. 31 (1993) 1961–1963.
Shapiro, E. D., Gerber, M. A., Holabird, N. B., Berg, A. T., Feder, H. M. Jr., Bell, G. L., Rys, P. N., Persing, D. H. A controlled trial of antimicrobial prophylaxis for Lyme disease after deer-tick bites. N. Engl. J. Med. 327 (1992) 1769–1773.
Magid, D., Schwartz, B., Craft, J., Schwartz, J. S. Prevention of Lyme disease after tick bites. A cost-effectiveness analysis. N. Engl. J. Med. 327 (1992) 534–541.
Luft, B. J., Dattwyler, R. J. Treatment of Lyme borreliosis. Rheum. Dis. Clin. North Am. 15 (1989) 747–755.
Haupl, T., Hahn, G., Rittig, M., Krause, A., Schoerner, C., Schonherr, U., Kalden, J. R., Burmester, G. R. Persistence ofBorrelia burgdorferi in ligamentous tissue from a patient with chronic Lyme borreliosis. Arthritis Rheum. 36 (1993) 1621–1626.
Klempner, M. S., Noring, R., Rogers, R. A. Invasion of human skin fibroblasts by the Lyme disease spirochete,Borrelia burgdorferi. J. Infect. Dis. 167 (1993) 1074–1081.
Wahlberg, P., Granlund, H., Nyman, D., Panelius, J., Seppala, I. Treatment of late Lyme borreliosis. J. Infect. 29 (1994) 255–261.
Lawrence, C., Lipton, R. B., Lowy, F. D., Coyle, P. K. Seronegative chronic relapsing neuroborreliosis. European Neurology 35 (1995) 113–117.
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Ziska, M.H., Donta, S.T. & Demarest, F.C. Physician preferences in the diagnosis and treatment of Lyme disease in the United States. Infection 24, 182–186 (1996). https://doi.org/10.1007/BF01713336
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DOI: https://doi.org/10.1007/BF01713336