Summary
Three cases are reported of lymphangiomyomatosis with pulmonary and abdominal manifestations. Two had a chylous pleura effusion, while the third presented a retroperitoneal manifestation, which was completely resectable. Antiestrogen therapy with tamoxifen was administered in all three cases. Two patients died of pulmonary progression after 4 months of therapy. The third is still alive, with stable disease for more than 6 years, and has been receiving tamoxifen for 66 months. These observations indicate that antiestrogen treatment may be as effective as oophorectomy when started at an early stage of the disease.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Banner AS, Carrington CB, Emory WB, Kittle F, Leonard G, Ringus J, Taylor P, Addington WW (1981) Efficacy of oophorectomy in lymphangioleiomyomatosis and benign metastasizing leiomyoma. N Engl J Med 305:204–209
Banner AS, Carrington CB (1981) Oophorectomy in lymphangioleiomyomatosis and benign metastasizing leiomyoma. N Engl J Med 305:1417
Carrington CB, Cugell Gaensler EA, Marks A, Redding RA, Schaaf JT, Tomasian A (1977) Lymphangioleiomyomatosis. Am Rev Resp Dis 116:977–995
Corrin B, Liebow AA, Friedman PJ (1975) Pulmonary lymphangiomyomatosis. Am J Pathol 79:348–367
Hiller E, Rosenow EC, Olsen AM (1972) Pulmonary manifestations of the yellow nail syndrome. Chest 61:452–845
Joliat G, Stalder H, Kapanci Y (1973) Lymphangiomatosis: a clinicoanatomical entity. Cancer 31:455–461
Kitzsteiner K, Mallen RG (1980) Pulmonary angiomyomatosis: treatment with castration. Cancer 46:2248–2249
Kitzsteiner K, Mallen RG (1981) Pulmonary lymphangiomyomatosis. N Engl J Med 305:978
Miller WT, Cornog JL, Sullivan MA (1971) Lymphangiomatosis — a clinical roentgenological-pathological syndrome. Am J Roentgenol 111:565–572
Shuman RL, Engelman R, Kittle CF (1979) Pulmonary lymphangiomyomatosis. Ann Thorac Surg 27:70–75
Tomasian A, Greenberg MS, Rumerman H (1982) Tamoxifen for lymphangioleiomyomatosis. N Engl J Med 306:745–746
Winter JA (1981) Oophorectomy in lymphangioleiomyomatosis and benign metastisizing leiomyoma. N Engl J Med 305:1416
Wolff M (1973) Lymphangiomyoma: clinicopathologic study and ultrastructural confirmation of its histogenesis. Cancer 31:988–1007
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Clemm, C., Jehn, U., Wolf-Hornung, B. et al. Lymphangiomyomatosis: A report of three cases treated with tamoxifen. Klin Wochenschr 65, 391–393 (1987). https://doi.org/10.1007/BF01745582
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01745582