Abstract
Concentrations of chlorinated hydrocarbons and polyclorinated biphenyls (PCB) were determined by capillary column gas chromatography in samples of bone marrow from 38 children with leukaemia (16 samples/pools) and 15 control (5 pools). The highest mean and median concentrations were detected for total PCB (mean=3.568 mg/kg fat basis/median 2.904 mg/kg) followed by the sum of the dichlorodiphenyltrichloroethane metabolites (1.775/1.059 mg/kg), hexachlorobenzene 0.354/0.260 mg/kg), the sum of the hexachlorocyclohexane isomers (0.133/0.093 mg/kg) and dieldrin (0.109/0.063 mg/kg). The CHC and PCB concentrations in bone marrow were two- to threefold higher than in fat tissue. Comparing children with and without leukaemia similar concentrations of CHC and PCB were found.
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Abbreviations
- CHC:
-
chlorinated hydrocarbons
- DDE:
-
dichlorodiphenyldichloroethylene
- DDT:
-
dichlorodiphenyltrichloroethane
- HCB:
-
hexachlorobenzene
- HCH:
-
hexachlorocyclohexane
- PCB:
-
polychlorinated biphenyls
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Scheele, J., Teufel, M. & Niessen, K.H. Chlorinated hydrocarbons in the bone Marrow of children: Studies on their association with leukaemia. Eur J Pediatr 151, 802–805 (1992). https://doi.org/10.1007/BF01957928
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DOI: https://doi.org/10.1007/BF01957928