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Age-related decrease in serum 25-hydroxyvitamin D concentrations in the frail elderly: a longitudinal study

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Abstract

Several cross-sectional studies have demonstrated an age-related decrease in serum 25-hydroxyvitamin D [25(OH)D] concentrations. No prospective studies, however, have been conducted to examine this correlation to date. The objectives of this study were to measure age-related changes in serum 25(OH)D concentrations and to identify predictors of change in serum 25(OH)D concentrations in the frail elderly during a 2-year follow-up period. Eighty elderly subjects (48 women and 32 men) were selected from people utilizing the long-term care insurance system in a community in Japan. All subjects participated in both the baseline and follow-up (2 years later) medical examinations. Baseline measurements included age, height, body mass index, and weight. Additionally, levels of activities of daily living (Barthel index), grip strength, lifestyle, serum 25(OH)D, intact parathyroid hormone (PTH), albumin, total protein, and creatinine concentrations were also determined at baseline. The average age of the subjects was 82.1 years (SD, 8.8). The 2-year decrease in serum 25(OH)D concentrations was calculated to be 6 nmol/l. Multiple linear regression analyses found that the 2-year change (Δ) in the log-transformed 25(OH)D was associated with Δalbumin (β = 0.503, R 2 = 0.288, P < 0.0001), and Δlog-transformed intact PTH was associated with baseline creatinine (β = 0.453, R 2 = 0.142, P = 0.0006) and Δlog-transformed 25(OH)D (β = −0.512, R 2 = 0.103, P = 0.0037). In conclusion, serum 25(OH)D concentrations decreased in the 2-year follow-up. This information is useful for the maintenance of vitamin D status and prevention of vitamin D insufficiency in the frail elderly.

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References

  1. HA Bischoff-Ferrari E Giovannucci WC Willett T Dietrich B Dawson-Hughes (2006) ArticleTitleEstimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes Am J Clin Nutr 84 18–28 Occurrence Handle16825677 Occurrence Handle1:CAS:528:DC%2BD28XntVertb8%3D

    PubMed  CAS  Google Scholar 

  2. MS Calvo SJ Whiting CN Barton (2005) ArticleTitleVitamin D intake: a global perspective of current status J Nutr 135 310–316 Occurrence Handle15671233 Occurrence Handle1:CAS:528:DC%2BD2MXhsVKjurc%3D

    PubMed  CAS  Google Scholar 

  3. HA Bischoff-Ferrari T Dietrich EJ Orav B Dawson-Hughes (2004) ArticleTitlePositive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults Am J Med 116 634–639 Occurrence Handle15093761 Occurrence Handle10.1016/j.amjmed.2003.12.029 Occurrence Handle1:CAS:528:DC%2BD2cXjt1SisrY%3D

    Article  PubMed  CAS  Google Scholar 

  4. D Feskanich WC Willett GA Colditz (2003) ArticleTitleCalcium, vitamin D, milk consumption, and hip fractures: a prospective study among postmenopausal women Am J Clin Nutr 77 504–511 Occurrence Handle12540414 Occurrence Handle1:CAS:528:DC%2BD3sXptVentA%3D%3D

    PubMed  CAS  Google Scholar 

  5. FM Gloth SuffixIII CM Gundberg BW Hollis JG Haddad JD Tobin (1995) ArticleTitleVitamin D deficiency in homebound elderly persons JAMA 274 1683–1686 Occurrence Handle7474272 Occurrence Handle10.1001/jama.274.21.1683

    Article  PubMed  Google Scholar 

  6. M Nashimoto K Nakamura S Matsuyama M Hatakeyama M Yamamoto (2002) ArticleTitleHypovitaminosis D and hyperparathyroidism in physically inactive elderly Japanese living in nursing homes: relationship with age, sunlight exposure, and activities of daily living Aging Clin Exp Res 14 5–12 Occurrence Handle12027153 Occurrence Handle1:STN:280:DC%2BD383os1Smug%3D%3D

    PubMed  CAS  Google Scholar 

  7. J MacLaughlin MF Holick (1985) ArticleTitleAging decreases the capacity of human skin to produce vitamin D3 J Clin Invest 76 1536–1538 Occurrence Handle2997282 Occurrence Handle1:CAS:528:DyaL2MXlvFeku7c%3D Occurrence Handle10.1172/JCI112134

    Article  PubMed  CAS  Google Scholar 

  8. B Burnand D Sloutskis F Gianoli J Cornuz M Rickenbach F Paccaud P Burckhardt (1992) ArticleTitleSerum 25-hydroxyvitamin D: distribution and determinants in the Swiss population Am J Clin Nutr 56 537–542 Occurrence Handle1503066 Occurrence Handle1:CAS:528:DyaK3sXjsl2ltQ%3D%3D

    PubMed  CAS  Google Scholar 

  9. R Dubbelman JHP Jonxis FAJ Muskiet AEC Saleh (1993) ArticleTitleAge-dependent vitamin D status and vertebral condition of white women living in Curaçao (The Netherlands Antilles) as compared with their counterparts in The Netherlands Am J Clin Nutr 58 106–109 Occurrence Handle8317380 Occurrence Handle1:STN:280:DyaK3szgsVaqsw%3D%3D

    PubMed  CAS  Google Scholar 

  10. SS Sherman BW Hollis JD Tobin (1990) ArticleTitleVitamin D status and related parameters in a healthy population: the effects of age, sex, and season J Clin Endcrinol Metab 71 405–413 Occurrence Handle1:CAS:528:DyaK3cXlvFSitbk%3D

    CAS  Google Scholar 

  11. K Nakamura M Nashimoto Y Hori M Yamamoto (2000) ArticleTitleSerum 25-hydroxyvitamin D levels and related dietary factors in peri- and postmenopausal Japanese women Am J Clin Nutr 71 1161–1165 Occurrence Handle10799378 Occurrence Handle1:CAS:528:DC%2BD3cXivFymsLc%3D

    PubMed  CAS  Google Scholar 

  12. K Nakamura T Nishiwaki K Ueno M Yamamoto (2005) ArticleTitleSerum 25-hydoroxyvitamin D levels and activities of daily living in noninstitutionalized elderly Japanese requiring care J Bone Miner Metab 23 488–494 Occurrence Handle16261457 Occurrence Handle10.1007/s00774-005-0633-4 Occurrence Handle1:CAS:528:DC%2BD2MXhtFKktrzJ

    Article  PubMed  CAS  Google Scholar 

  13. HJ Roth I Zahn R Alkier H Schmidt (2001) ArticleTitleValidation of the first automated chemiluminescence protein-binding assay for the detection of 25-hydroxycalciferol Clin Lab 47 357–365 Occurrence Handle11499797 Occurrence Handle1:CAS:528:DC%2BD3MXmtVGmt7Y%3D

    PubMed  CAS  Google Scholar 

  14. DT Wade C Collin (1988) ArticleTitleThe Barthel ADL index: a standard measure of physical disability? Int Disabil Stud 10 64–67 Occurrence Handle3042746 Occurrence Handle1:STN:280:DyaL1c3pvVKhtg%3D%3D

    PubMed  CAS  Google Scholar 

  15. T Kwok MN Whitelaw (1991) ArticleTitleThe use of armspan in nutritional assessment of the elderly J Am Geriatr Soc 39 492–496 Occurrence Handle2022801 Occurrence Handle1:STN:280:DyaK3M3hslegsw%3D%3D

    PubMed  CAS  Google Scholar 

  16. D Storm R Eslin ES Porter K Musgrave D Vereault C Patton C Kessenich S Mohan T Chen MF Holick CJ Rosen (1998) ArticleTitleCalcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial J Clin Endocrinol Metab 83 3817–3825 Occurrence Handle9814452 Occurrence Handle10.1210/jc.83.11.3817 Occurrence Handle1:CAS:528:DyaK1cXntlOisb4%3D

    Article  PubMed  CAS  Google Scholar 

  17. ME Salive J Cornoni-Huntley CL Phillips JM Guralnik HJ Cohen AM Ostfeld RB Wallace (1992) ArticleTitleSerum albumin in older persons: relationship with age and health status J Clin Epidemiol 45 213–221 Occurrence Handle1569418 Occurrence Handle10.1016/0895-4356(92)90081-W Occurrence Handle1:STN:280:DyaK383jsFKgtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  18. H Klonoff-Cohen EL Barrett-Connor SL Edelstein (1992) ArticleTitleAlbumin levels as a predictor of mortality in the healthy elderly J Clin Epidemiol 45 207–212 Occurrence Handle1569417 Occurrence Handle10.1016/0895-4356(92)90080-7 Occurrence Handle1:STN:280:DyaK383jsFKgtg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  19. G Zuliani F Romagnoni S Volpato L Soattin V Leoci MC Bollini M Buttarello D Lotto R Fellin (2001) ArticleTitleNutritional parameters, body composition, and progression of disability in older disabled residents living in nursing homes J Gerontol A Biol Sci Med Sci 56 M212–M216 Occurrence Handle11283193 Occurrence Handle1:STN:280:DC%2BD3M3js12hug%3D%3D

    PubMed  CAS  Google Scholar 

  20. D Thiébaud P Burckhardt M Costanza D Sloutskis D Gilliard F Quinodoz AF Jacquet B Burnand (1997) ArticleTitleImportance of albumin, 25(OH)-vitamin D and IGFBP-3 as risk factors in elderly women and men with hip fracture Osteoporos Int 7 457–462 Occurrence Handle9425504 Occurrence Handle10.1007/s001980050033

    Article  PubMed  Google Scholar 

  21. AV Lunde E Barrett-Connor DJ Morton (1998) ArticleTitleSerum albumin and bone mineral density in healthy older men and women: the Rancho Bernardo Study Osteoporos Int 8 547–551 Occurrence Handle10326059 Occurrence Handle10.1007/s001980050097 Occurrence Handle1:STN:280:DyaK1M3lsl2juw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  22. DD Bikle E Gee B Halloran MA Kowalski E Ryzen JG Haddad (1986) ArticleTitleAssessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein J Clin Endocrinol Metab 63 954–959 Occurrence Handle3745408 Occurrence Handle1:CAS:528:DyaL28XlvV2rtrs%3D Occurrence Handle10.1210/jcem-63-4-954

    Article  PubMed  CAS  Google Scholar 

  23. DH Sullivan (2001) ArticleTitleWhat do the serum proteins tell us about our elderly patients? J Gerontol A Biol Sci Med Sci 56 M71–M74 Occurrence Handle11213278 Occurrence Handle1:STN:280:DC%2BD3M7jsVOksQ%3D%3D

    PubMed  CAS  Google Scholar 

  24. Meunier PJ, Chapuy ML (2005) Vitamin D insufficiency in adults and elderly. In: Feldman D, Pike JW, Glorieux FH (eds) (2005) Vitamin D, 2nd edn. Elsevier Academic Press, San Diegopp 1085–1100

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Authors and Affiliations

  1. Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan

    Kazutoshi Nakamura & Masaharu Yamamoto

  2. Faculty of Health Care, Tokyo Healthcare University, Tokyo, Japan

    Tomoko Nishiwaki

  3. Department of Nursing, Faculty of Medical Technology, Teikyo University, Tokyo, Japan

    Kimiko Ueno

Authors
  1. Kazutoshi Nakamura
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  2. Tomoko Nishiwaki
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  3. Kimiko Ueno
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  4. Masaharu Yamamoto
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Correspondence to Kazutoshi Nakamura.

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Nakamura, K., Nishiwaki, T., Ueno, K. et al. Age-related decrease in serum 25-hydroxyvitamin D concentrations in the frail elderly: a longitudinal study. J Bone Miner Metab 25, 232–236 (2007). https://doi.org/10.1007/s00774-007-0755-y

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  • DOI: https://doi.org/10.1007/s00774-007-0755-y

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