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Topiramate and Propranolol for Prophylaxis of Migraine

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Abstract

Objective

To compare efficacy and safety of topiramate (TPM) and propranolol for migraine prophylaxis in children.

Methods

In a parallel single-blinded randomized clinical trial, 5–15 y-old referred migraineurs to Pediatric Neurology Clinic of Shahid Sadoughi Medical Sciences University, Yazd, Iran from May through October 2011, were evaluated. Patients were distributed into two groups, 50 of whom were treated with 3 mg/kg/d of topiramate (TPM) and another group of 50, were treated with 1 mg/kg of propranolol for 3 mo. Primary endpoints were efficacy in reduction of monthly frequency, severity, duration and headache related disability. Secondary outcome was clinical side effects.

Results

Fifty two girls and 48 boys with mean age of 10.34 ± 2.31 y were evaluated. Monthly frequency, severity and duration of headache decreased with TPM, from 13.88 ± 8.4 to 4.13 ± 2.26 attacks, from 6.32 ± 1.93 to 2.8 ± 2.12, and from 2.36 ± 1.72 to 0.56 ± 0.5 h, respectively. Monthly frequency, severity and duration of headache also decreased with propranolol from 16.2 ± 6.74 to 8.8 ± 4.55 attacks, from 6.1 ± 1.54 to 4.8 ± 1.6 and from 2.26 ± 1.26 to 1.35 ± 1.08 h, respectively. Pediatric Migraine Disability Assessment score reduced from 31.88 ± 9.72 to 9.26 ± 7.21 with TPM and from 33.08 ± 8.98 to 23.64 ± 9.88 with propranolol. Transient mild side effects were seen in 18 % of TPM and in 10 % of propranolol (P = 0.249) groups.

Conclusions

Topiramate is more effective than propranolol for pediatric migraine prophylaxis.

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Conflict of Interest

None.

Role of Funding Source

This study was funded by a grant from the Research Deputy of Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

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Authors and Affiliations

  1. Department of Pediatrics, Research Center of Pain, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Razieh Fallah

  2. Department of Pediatrics, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Mohammad Saleh Divanizadeh

  3. Department of Pediatrics, Growth Disorders of Children Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Mehran Karimi

  4. Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Mehrdad Mirouliaei

  5. Department of Computer Engineering, Engineering and Basic Sciences Faculty, Islamic Azad University, Sari Branch, Sari, Iran

    Ali Shamszadeh

  6. Shahid Sadoughi Hospital, Ave - Sina Blvd, Shahid Ghandi Blvd, Yazd, Islamic Republic of Iran

    Mehran Karimi

Authors
  1. Razieh Fallah
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  2. Mohammad Saleh Divanizadeh
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  3. Mehran Karimi
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  4. Mehrdad Mirouliaei
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  5. Ali Shamszadeh
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Corresponding author

Correspondence to Mehran Karimi.

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Fallah, R., Divanizadeh, M.S., Karimi, M. et al. Topiramate and Propranolol for Prophylaxis of Migraine. Indian J Pediatr 80, 920–924 (2013). https://doi.org/10.1007/s12098-013-0976-0

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  • DOI: https://doi.org/10.1007/s12098-013-0976-0

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