Clinical study
Infectious mononucleosis hepatitis: A clinicopathologic study

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Abstract

  • 1.

    1. Twenty-two young men with clinical manifestations of infectious mononucleosis were studied by liver function tests and liver biopsy in an attempt to clarify aspects of hepatitis in this disease.

  • 2.

    2. Function tests and/or biopsy indicated hepatic involvement in all cases, biopsy specimens showing return to normal in all but one instance within five weeks.

  • 3.

    3. One case of persistent hepatitis, studied by function tests and serial biopsies, showed continuation of the disease for approximately eight months, and is still being followed up.

  • 4.

    4. In three of the twenty-two cases heterophil antibody determinations remained below diagnostic evels. All three had abnormal liver function tests and two biopsy specimens yielded positive findings despite lack of confirmation of the diagnosis by the Paul-Bunnell test.

  • 5.

    5. The significance of these results in the light of previous studies by other observers is discussed.

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  • Cited by (0)

    1

    From the Medical Service, United States Army Hospital, Fort Knox, Kentucky.

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