Domperidone in defective and insufficient lactation

https://doi.org/10.1016/0028-2243(85)90042-5Get rights and content

Abstract

The clinical use of anti-dopaminergic drugs to stimulate plasma PRL levels, to induce lactogenesis and maintain an adequate lactation has been widely suggested, taking into consideration the main inhibitory role of hypothalamic dopamine on PRL secretion. We therefore studied the effects of domperidone (DOM), a direct anti-dopaminergic drug with a low tendency to be secreted in the milk and which does not cross the blood-brain barrier, on inducing lactogenesis in 8 puerperal women with a history of defective lactogenesis (group A) and inducing galactopoiesis in 9 puerperal women who showed 2 weeks after delivery an insufficient lactation (group B). A placebo treatment was performed in 7 and 8 puerperal women with the same characteristics of group A and B, respectively. PRL plasma levels were assayed in basal conditions and after suckling from the 2nd to the 5th day of puerperium in group A and through a 10-day treatment in group B. In both groups domperidone-treated subjects always showed baseline PRL levels and daily milk yield significantly higher than those of the placebo group (P < 0.01). The lack of any side-effects and the positive results suggest a high usefulness of such a drug in inducing and/or maintaining successful breast feeding, which is at present considered so important for a healthy development of infants.

References (23)

  • T. Aono et al.

    The initiation of human lactation and prolactin response to suckling

    J. clin. Endocr. Metab.

    (1977)
  • T. Aono et al.

    Augmentation of puerperal lactation by oral administration of sulpiride

    J. clin. Endocr. Metab.

    (1979)
  • R. Brun Del Re et al.

    Prolactin inhibition and suppression of puerperal lactation by a Br-ergocryptine (CB 154). A comparison with estrogen

    Obstet. and Gynec.

    (1973)
  • H. De Gezelle et al.

    Metoclopramide and breast milk

    Europ. J. Obstet. Gynec. reprod. Biol.

    (1983)
  • E. Del Pozo et al.

    The inhibition of prolactin secretion in man by CB 154 (2-Br-x-ergocryptine)

    J. clin. Endocr. Metab.

    (1978)
  • J.A. Engel et al.

    Behavioural and biochemical effects in off-spring of nursing rats exposed to dopamine receptor antagonists

  • S. Franks et al.

    Pregnancy and lactation after pituitary surgery

    Brit. med. J.

    (1977)
  • A.G. Frantz et al.

    Studies on prolactin in man

    Rec. Progr. Hormone Res.

    (1972)
  • G.J. Hofmeyr et al.

    Domperidone and lactation

    The Lancet

    (1983)
  • P.W. Howie et al.

    The relationship between suckling-induced prolactin response and lactogenesis

    J. clin. Endocr. Metab.

    (1980)
  • A. Kauppila et al.

    Metoclopramide increases prolactin release and milk secretion in puerperium without stimulating the secretion of thyrotropin and thyroid hormones

    J. clin. Endocr. Metab.

    (1981)
  • Cited by (0)

    View full text