Vertical transmission of human papillomavirus from infected mothers to their newborn babies and persistence of the virus in childhood☆,☆☆,★,★★
Section snippets
Subjects
The current study consisted of 98 children born to 66 mothers included in a prospective follow-up program conducted for cervical HPV infections in Kuopio University Hospital since 1981.14 The group of 66 mothers included 20 women in the treatment group and 46 in the follow-up group (no treatment for genital condylomas). Altogether, >150 mothers were invited to bring their children (>240) to the oral examination; of these, 66 mothers responded. The relatively high rate of nonresponders might be
RESULTS
HPV DNA was found in 31 of the 98 (31.6%) oral scrapings. With MY11 and MY09 HPV primers, 12 of 98 were positive for HPV DNA in the electrophoresis gel and in the subsequent hybridization. Nineteen of the positive samples were not found in the polymerase chain reaction gel but become positive when hybridized. However, polymerase chain reaction with HPV primers P1 and P2 (targeting the E1 region) resulted in a large number of positive amplifications (in >50% of samples) that could not be
COMMENT
The knowledge of the transmission routes of HPV is of importance because of the significant consequences of the infection. These include genital warts, cervical dysplasia, and, rarely, cervical cancer. There are also social and legal implications when this infection occurs in children. The search for viral reservoir is of major importance to the full elucidation of the modes of HPV transmission.
Sexual transmission of HPV was first proposed by Barrett et al.17 in 1954 when they noted the
Acknowledgements
We thank Mr. Jari Meklin, Mrs. Helena Kemiläinen, Mrs. Kaarina Hoffren, Mrs. Marja Nykänen, and Mrs. Aija Korkalainen for skillful technical assistance.
References (25)
- et al.
Human papillomavirus infections in respiratory tract
Am J Otolaryngol
(1992) - et al.
Mechanism for human papillomavirus transmission at birth
AM J OBSTET GYNECOL
(1989) - et al.
Possible transplacental transmission of human papillomaviruses
AM J OBSTET GYNECOL
(1992) - et al.
Human papillomavirus (HPV) type 16 in semen of partners of women with HPV infection
Lancet
(1992) - et al.
Human papillomavirus (HPV) infections and their associations with oral disease
J Oral Pathol Med
(1991) - et al.
Clinical spectrum of HPV infection in the neonate and child
Clin Pract Gynecol
(1989) - et al.
Respiratory papillomatosis: etiological relation to genital tract papillomaviruses
Prog Med Virol
(1984) - et al.
Dot blot hybridization in detection of human papillomavirus (HPV) infections in the oral cavity of women with genital HPV infections
Oral Microbiol Immunol
(1992) - et al.
Southern blot hybridization and PCR in detection of oral human papillomavirus (HPV) infections in women with genital HPV infections
J Oral Pathol Med
(1992) - et al.
Transmission of human genital papillomavirus disease: comparison of data from adults and children
Pediatrics
(1993)
Children with condylomata acuminata
J Fam Pract
Rarity of cesarean delivery in cases of juvenile-onset respiratory papillomatosis
Obstet Gynecol
Cited by (134)
Human papilloma virus vaccines: A comprehensive narrative review
2023, Cancer Treatment and Research CommunicationsThe vaginal microbiome: A complex milieu affecting risk of human papillomavirus persistence and cervical cancer
2022, Current Problems in CancerHuman papillomavirus vaccination history and diagnosis of cervical intraepithelial neoplasia grade ≥2 severe lesions among a cohort of women who underwent colposcopy in Kaiser Permanente Southern California
2021, American Journal of Obstetrics and GynecologyCitation Excerpt :Other nonsexual transmissions, including skin-to-skin transmission and vertical transmission from mothers to babies.25 To this end, persistent HPV infection has been detected in children who acquired HPV from vertical transmission for years, with 80% of infections by HPV types 16 and 18.26 This observation supported the findings of HPV infection, including HPV types 16 and 18, in sexually inexperienced children, adolescent, and young women in a previous study.27,28
HPV Vaccination Recommendation Practices among Adolescent Health Care Providers in 5 Countries
2018, Journal of Pediatric and Adolescent GynecologyCitation Excerpt :Approximately 85% of cervical cancer cases occur in less developed regions, with high incidence in sub-Saharan Africa, South Asia, and Latin America.1 Almost all cases of cervical cancer (99%) are attributable to human papillomavirus (HPV), a sexually transmitted infection affecting over 290 million women worldwide.2,3 With widespread use, prophylactic vaccination has the potential to markedly reduce the number of HPV infections, having been shown to decrease quadrivalent vaccine-associated type HPV prevalence by 77% among 18- to 24-year-olds in Australia,4 and by 56% among 14- to 19-year-olds in the United States despite only 32% coverage.5
The human papillomavirus (HPV)-related cancer biology: An overview
2018, Biomedicine and PharmacotherapyHLA-G and vertical mother-to-child transmission of human papillomavirus infection
2018, Human ImmunologyCitation Excerpt :The prevalence is shown to be highest among women and men around their sexual debut, and nearly all sexually active women and male will be infected with HPV in their lifetime [1,2]. However, HPV-infection can be transmitted in early life by vertical transmission from a mother to her child [3–6]. This transmission could occur in fertilization, during pregnancy (prenatal), at delivery or during the perinatal period [3,4].
- ☆
From the Departments of Pathology,aOral Pathology,band Gynecology and Obstetrics,cUniversity of Kuopio, and the Medicity Research Laboratory, Faculty of Medicine,dand the Department of Oral Pathology,eUniversity of Turku.
- ☆☆
Supported by grants from the North-Savo Fund of the Finnish Cultural Foundation, the Finnish Dental Society, the North-Savo Fund of the Finnish Cancer Society, and a joint Research Grant from British American Tobacco Company and Frabrique de Tabac Reunies, S.A.
- ★
Reprint requests: Mirja Puranen, DDS, Department of Pathology, University of Kuopio, P.O. Box 1627, Fin-70211 Kuopio, Finland.
- ★★
0002-9378/96 $5.00 + 0 6/1/67234