Is cyclic vomiting syndrome related to migraine?☆,☆☆,★,★★
Section snippets
Study Population
From 1986 to 1998, 277 children <18 years of age presented to the Gastroenterology Service at Columbus Children’s Hospital with at least 3 discrete episodes of vomiting. Of those children, 9 had incomplete information and could not be contacted, 27 had a non-gastrointestinal disorder (eg, brainstem glioma), and 27 had a gastrointestinal disorder (eg, malrotation) identified that was thought, based on its response to treatment, to cause or contribute to the vomiting as previously described.14
RESULTS
Of the 214 children with CVS, 176 (82%) met the criteria for migraine-related CVS and 38 (18%) did not. Among those in the migraine subset, 170 had a positive family history of migraine headaches (55 of whom later experienced migraine headaches), and the 6 who did not have a positive family history subsequently experienced headaches that met the International Headache Criteria for migraines.19 Among those with a family history of migraine, 107 (63%) had it identified on the maternal side alone,
DISCUSSION
Our study of a large cohort of children with CVS indicates that the vast majority of cases may be related to migraines. This conclusion is based on the use of 1 of 2 key criteria to classify affected patients into migraine-associated and non-migraine CVS subgroups—either a positive family history of migraines or subsequent development of migraines in the patient. Our findings support the schema that migraine may present in different patterns during childhood: cyclic vomiting in toddlers and
Acknowledgements
We thank Jan Brickman for assistance of with the references and Brad Pfau, MD, Kim-Ahn Vu, MD, Sam Chiao, Nirav Rana, Allison Robbins, and Ankur Rana for their work on the CVS database.
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2022, Cyclic Vomiting Syndrome and Cannabinoid HyperemesisClinical and pathophysiological relationship between migraines and cyclic vomiting syndrome
2022, Cyclic Vomiting Syndrome and Cannabinoid HyperemesisCyclic vomiting syndrome subtypes—do they provide insight into cyclic vomiting syndrome pathogenesis?
2022, Cyclic Vomiting Syndrome and Cannabinoid Hyperemesis
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Supported by Glaxo-Wellcome Inc, the Cyclic Vomiting Syndrome Association, and the Roessler Fund at the Ohio State University.
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Conflict of interest: Dr Li receives research support from Glaxo Wellcome, Inc.
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Reprint requests: B U. K. Li, MD, Division of Gastroenterology, Columbus Children’s Hospital, 700 Children’s Dr, Columbus, OH 43205-2696.
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0022-3476/99/$8.00 + 0 9/21/97120