Dermal, subcutaneous, and tendon xanthomas: Diagnostic markers for specific lipoprotein disorders*,**

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Abstract

Many patients with lipoprotein disorders are at increased risk for the development of premature atherosclerosis and, less commonly, other disorders that cause systemic morbidity. In some of these patients, xanthomas also develop and provide cutaneous markers for the lipoprotein disorder. As advances in molecular biology refine our understanding of lipoprotein metabolism, it has become increasingly clear that several types of xanthomas are associated with specific disease states. This article presents a differential diagnosis of xanthomas that incorporates contemporary thinking about lipoprotein disorders and focuses on the relationship between abnormalities in lipoprotein metabolism, content, or structure and the development of specific xanthomas.

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  • Cited by (0)

    *

    Winner of the Gold Award for Teaching Value Poster, 44th Annual Meeting of the American Academy of Dermatology, Las Vegas, NV, Dec. 7–12, 1985.

    **

    Financial support for color reproduction was received from Ortho Pharmaceutical Corporation, Raritan, NJ.

    1

    From the Departments of Dermatology and Internal Medicine, University of Texas Southwestern Medical Center at Dallas.

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