Preventive cardiologyNon–High-Density Lipoprotein and Very-Low-Density Lipoprotein Cholesterol and Their Risk Predictive Values in Coronary Heart Disease
Section snippets
Methods
The analytic samples from each of the cohorts were comparably defined (Table 1). The pooled sample consisted of men and women who were (1) aged ≥30 years, (2) free of CHD at baseline, and (3) known to have fasted overnight for ≥9 hours. Details about the design of the Framingham Heart Study are given elsewhere.1, 2
Results
A total of 5,794 subjects (2,693 men, 3,101 women) from the Framingham Cohort Study and the Framingham Offspring Study were pooled for analyses (Table 2). The average follow-up time was about 15 years. During the follow-up, a total of 990 incident CHD events (618 in men, 372 in women) were recorded. The CHD incidence rate was 107.0/10,000 subject–years (149.7 in men, 72.7 in women). All lipid parameters were strongly associated with CHD risk in men and women (Table 3). Because the results for
Discussion
The results from this study support the conclusions that VLDL cholesterol is an independent predictor of CHD risk and that non-HDL cholesterol overall appears to be a better predictor of CHD risk than LDL cholesterol. These conclusions appear to be valid for the entire population and when TG levels are either <200 or ≥200 mg/dl.
When introduced into a multivariate model individually, the increases in CHD risk associated with 1 mg/dl increases in the levels of non-HDL cholesterol and LDL
Acknowledgment
This report was prepared using a limited access data set obtained from the National Heart, Lung, and Blood Institute, Bethesda, Maryland, and does not necessarily reflect the opinions or views of the individual studies or the National Heart, Lung, and Blood Institute.
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The Framingham Heart Study is conducted and supported by the National Heart, Lung, and Blood Institute, Bethesda, Maryland, in collaboration with the study investigators.