Efficacy and safety profile of a single dose of hydromorphone compared with morphine in older adults with acute, severe pain: A prospective, randomized, double-blind clinical trial
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Cited by (32)
A Randomized Study of Intravenous Hydromorphone Versus Intravenous Acetaminophen for Older Adult Patients with Acute Severe Pain
2022, Annals of Emergency MedicineCitation Excerpt :Intravenous opioids are the mainstay of treating acute severe pain in the ED setting.7 Among older patients, intravenous hydromorphone is effective and safe using both weight-based dosing (0.0075 mg/kg) and fixed 0.5 mg doses.8,9 However, because of the fear of adverse medication reactions, such as respiratory depression or hypotension; medication interactions; and long-term sequelae, such as opioid use disorder and chronic pain syndromes, some have called for minimizing the use of opioids in the ED.
Low-dose ketamine vs morphine for acute pain in the ED: A randomized controlled trial
2015, American Journal of Emergency MedicinePain management in the emergency department: A review
2014, Journal Europeen des Urgences et de ReanimationHydromorphone: Evolving to Meet the Challenges of Today's Health Care Environment
2013, Clinical TherapeuticsCitation Excerpt :Taken together, these characteristics make hydromorphone attractive therapeutically when a continuous subcutaneous infusion is indicated. In randomized, double-blind trials in patients with acute, severe pain, intravenous hydromorphone (0.0075–0.015 mg/kg) was shown to be an equally effective and well-tolerated alternative to intravenous morphine (0.05–0.1 mg/kg).36,37 A prospective, noncomparative cohort study in 269 adults with acute, severe pain found that a 2-mg intravenous dose of hydromorphone was efficacious.38
Randomized clinical trial of the 2 mg hydromorphone bolus protocol versus the "1+1" hydromorphone titration protocol in treatment of acute, severe pain in the first hour of emergency department presentation
2013, Annals of Emergency MedicineCitation Excerpt :Taking into consideration the heightened risk of adverse effects associated with administration of too large or too rapid a dose of intravenous opioid, we wished to develop a modified titration strategy appropriate to the constraints of the ED. After conducting a series of prospective interventional efficacy and safety studies examining different intravenous opioids administered in a range of doses during systematically varying intervals,20-27 we have reached a point at which we have selected 1 mg intravenous hydromorphone as our preferred incremental dose of opioid.22-24 The central question of this investigation is to determine the optimal dose of intravenous hydromorphone with which to initiate an ED pain protocol targeted at attainment of satisfactory analgesia within a reasonable timeframe.