Scientific paperCombination tramadol plus acetaminophen for postsurgical pain☆
Section snippets
Study design
Treatment of postsurgical pain with tramadol 37.5 mg plus APAP 325 mg (Ultracet; Ortho-McNeil, Raritan, NJ) was compared with codeine 30 mg plus APAP 300 mg and with placebo in a multicenter, randomized, double-blind, active- and placebo-controlled, parallel-group study. The study population consisted of approximately 300 patients in generally good health who had undergone a therapeutic arthroscopic procedure of the knee or shoulder or who had undergone abdominal surgery for inguinal or ventral
Demographics
After randomization (n = 306) was accomplished, the intention-to-treat population (n = 305) consisted of 152 patients undergoing abdominal surgery (49.8%) and 153 patients undergoing orthopedic (50.2%) procedures and included 215 (70.5%) men and 90 (29.5%) women. The patients had a mean age of 47.3 years (range 18 to 79 years), a mean baseline pain visual analog scale score of 62.9 mm, and a baseline pain intensity score of 2.2 (Table 1). The treatment groups were comparable with respect to
Comments
The results of this study show that postsurgical pain associated with arthroscopic procedures of the knee or shoulder or with abdominal hernia surgery was successfully decreased by treatment with 37.5 mg tramadol plus 325 mg APAP tablets. The combination of tramadol plus APAP was superior to placebo as an analgesic as measured by all primary (TOTPAR, SPID, and SPRID) and secondary efficacy outcomes (average daily pain relief, average daily pain intensity, final visit pain intensity, final visit
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Comparison of tramadol/acetaminophen fixed-dose combination, tramadol, and acetaminophen in patients undergoing ambulatory arthroscopic meniscectomy
2018, Acta Orthopaedica et Traumatologica TurcicaCitation Excerpt :The dual mechanism of action of the fixed-dose combination of tramadol/acetaminophen and potential for enhanced efficacy with combined medications decreases the rate of adverse events such as nausea, which is commonly seen, dizziness, vomiting, and respiratory depression.19 This issue would be expected and consistent with the decreased dose of tramadol and acetaminophen compared to other opioids; thus, paracetamol and tramadol are known to have a lower side effect profile.19 An advantage of tramadol over morphine and other opioids is its minimal effect on respiratory function.27
Tramadol hydrochloride/acetaminophen combination versus non-steroidal anti-inflammatory drug for the treatment of perioperative pain after total knee arthroplasty: A prospective, randomized, open-label clinical trial
2016, Journal of Orthopaedic ScienceCitation Excerpt :TRAM/APAP was superior to placebo for total pain relief, sum of pain intensity differences, and sum of pain relief and pain intensity differences for orthopedic and abdominal postoperative pain. For average daily pain relief, average daily pain intensity, and overall medication assessment, TRAM/APAP was superior to codeine plus APAP [12]. TRAM/APAP was shown to be effective for postoperative pain after arthroscopic surgery of knees and shoulders in 6 days.
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2014, Pain PracticeCitation Excerpt :Paracetamol is used for the management of mild-to-moderate pain and also has an antipyretic effect.23 The combination tablet tramadol/paracetamol was proven efficacious in pain of different origins,24–32 especially following orthopedic, abdominal surgery,33 hand surgery,34 and acute postoperative dental pain.35,36 It is also known that paracetamol in combination with a NSAID gives better pain relief than when using both separately.37
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This research was supported by Ortho-McNeil Pharmaceutical, Raritan, NJ.
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Members of the CAPSS-115 Study Group are listed in the Appendix.