Efficacy and tolerability of oxymorphone immediate release for acute postoperative pain after abdominal surgery: A randomized, double-blind, active- and placebo-controlled, parallel-group trial*
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Ketorolac, Oxymorphone, Tapentadol, and Tramadol: A Comprehensive Review
2017, Anesthesiology ClinicsCitation Excerpt :In single- and multiple-dose trials of oxymorphone IR,30 absorption of the drug is rapid, and the time of maximum plasma concentration (tmax) following PO administration was 0.5 hours. In a study using single or multiple doses of oxymorphone IR 20 to 30 mg, this observed tmax was consistent with the rapid onset of analgesia in 0.5 to 0.75 hours.32,33 The half-life of elimination for one dose of oxymorphone IR ranges from around 7.2 hours for 5 mg to 9.4 hours for 20 mg.22
Does co-administration of paroxetine change oxycodone analgesia: An interaction study in chronic pain patients
2010, Scandinavian Journal of PainClinical Approaches to Special Issues Related to Opioid Therapy
2009, Seminars in Oncology NursingCitation Excerpt :Oxymorphone, which has been available in rectal suppository form, has recently been made available in oral form, adding to the armamentarium of immediate-release and extended-release opioids for the management of acute pain and persistent pain. Oxymorphone was demonstrated to be effective and well tolerated in opioid-experienced patients with chronic low back pain in a 3-month, randomized, placebo-controlled study,21 as well as in studies of postsurgical pain,22-25 cancer pain,26 and moderate to severe pain from osteoarthritis.27-29 This opioid analgesic has low peak-to-trough fluctuation,30 and is not significantly metabolized by the cytochrome P450 enzymes CYP2C9 or CYP3A4.31
Endogenous opiates and behavior: 2007
2008, Peptides
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These results were presented in part at the 25th Annual Scientific Meeting of the American Pain Society, May 3–6, 2006, San Antonio, Texas, and the 22nd Annual Meeting of the American Academy of Pain Medicine, February 22–25, 2006, San Diego, California.