Controversy responseCongenital abnormalities in children born after assisted reproductive techniques: how much is associated with the presence of infertility and how much with its treatment?
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Cited by (26)
The prolonged disease state of infertility is associated with embryonic epigenetic dysregulation
2021, Fertility and SterilityHealth Outcomes of Children Conceived Through Assisted Reproductive Technology
2015, Handbook of Fertility: Nutrition, Diet, Lifestyle and Reproductive HealthLow-technology assisted reproduction and the risk of preterm birth in a hospital-based cohort
2015, Fertility and SterilityNeonatal outcome and birth defects in 6623 singletons born following minimal ovarian stimulation and vitrified versus fresh single embryo transfer
2012, European Journal of Obstetrics and Gynecology and Reproductive BiologyCitation Excerpt :After decades of research, convincing evidence suggests that assisted reproduction techniques are associated with approximately a 30–40% increase in the rate of birth defects when compared to naturally conceived children [25]. Reasons behind this phenomenon are unclear but it is hypothesized that patient characteristics related to infertility rather than specific ART techniques might be mainly responsible for the higher malformation rate [26]. Birth defect rates in ART children vary considerably (1.09–6.2%) between different studies due to methodological limitations [27].
Growth and development of children born after in vitro fertilization
2008, Fertility and SterilityCitation Excerpt :In view of multiple comparisons, careful interpretation of these results, due to increased risks of chance findings, is of great importance. It is still unclear whether the slightly increased risk of congenital malformations observed among infants born after IVF is inherent to factors associated with the underlying causes of infertility or factors associated with the IVF procedure (51, 56, 57). The need for further prospective surveillance and collection of detailed and accurate information on the duration and causes of infertility, exact information regarding maternal drug exposure, and other parental background characteristics has been recently underscored (53).
Infertile couples, assisted reproduction and increased risks to the children
2007, Reproductive BioMedicine Online