ReportClinical and histopathologic characteristics of nevus depigmentosus
Section snippets
Patients
We examined 60 Korean patients with ND who attended our institution between January 2001 and December 2004. In each patient, the diagnosis of ND was determined by clinical diagnostic criteria proposed by Coupe4 and Wood's light examination. The clinical data compiled included sex, age, age of onset, number of lesions, involved sites, shape and pattern of lesions, and associated systemic disease.
Stains and immunohistochemistry
Punch biopsies (2 mm) from lesional and perilesional normal-appearing (usually ≥6 cm distant) skin
Clinical findings
As shown in Table I, of the 60 patients with ND, 33 (55%) were male and 27 (45%) were female. Their ages ranged from 3 months to 35 years (mean 9.4 years, median 1.0 year) and onset age of ND ranged from immediately after birth to 13 years (mean 2.1 years). The earliest onset was immediately after birth, whereas in 19 patients (31.7%) it appeared after 3 years of age. In all, 27 patients (45%) had only one lesion, whereas 9 patients (15.0%) had more than 20 lesions. The trunk was the most
Discussion
ND is generally known to be a congenital, nonfamilial disorder characterized by hypopigmented lesion that remains stable over time. Although the clinical features of ND may appear similar to those of vitiligo, the clinical courses of ND are different from those of vitiligo.8 We investigated the clinicopathologic features of ND that are essential not only to diagnosis but also to understanding the pathogenesis of ND.
The development of ND usually takes place at an early age. However, sporadic
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2022, Clinics in DermatologyCitation Excerpt :In two series of patients with segmental pigmentation disorder (total N = 69),22,23 none had neurodevelopmental issues and <5% had minor potentially related anomalies. In three series including a total of 165 patients presenting to a dermatologist with a nevus depigmentosus (segmental in about half), <1% had an associated extracutaneous abnormality.56-58 A recent case-control study of 144 individuals with segmental pigmentation disorder followed for a median of 27 years confirmed that these lesions were more evident in individuals with darkly pigmented skin, nonprogressive, and not associated with extracutaneous manifestations.88
Hypopigmented macules in neurofibromatosis type 1: A case control study
2021, Journal of the American Academy of DermatologySnapshotDx Quiz: June 2020
2020, Journal of Investigative DermatologyNatural History of Nevus Depigmentosus: A Long-term Follow-up Study of 102 Cases
2023, Annals of DermatologyNeonatal Dermatosis
2023, Dermatology in Public Health Environments: A Comprehensive Textbook, Second Edition
Supported by a 2004 grant from the Department of Medical Sciences, The Graduate School, Ajou University.
Conflicts of interest: None identified.