ReviewBariatric surgery and psoriasis
Section snippets
Bariatric surgery and obesity
Bariatric surgery procedures, including the laparoscopic adjustable gastric banding (AGB), standard Roux-en-Y gastric bypass (RYGB), and laparoscopic sleeve gastrectomy, have been found to be safe and effective treatments for weight loss.12, 13 The number of bariatric surgeries worldwide has increased significantly in recent years, from 5000 surgeries between 1987 and 1989 to an estimated 350,000 in 2008.13 Traditionally, the procedures were thought to cause weight loss solely through
Bariatric surgery and psoriasis
Limited evidence suggests that patients with psoriasis who undergo bariatric surgery may experience improvement of psoriasis after surgery. This phenomenon was first described in 1977 after a patient underwent jejunoileal bypass.15 The patient had severe psoriasis and shortly after undergoing surgery, noticed significant improvement. After losing over 100 lb, the patient had only localized psoriasis 2 years after surgery.15
Three case reports have described similar results after patients
References (22)
- et al.
Prevalence of cardiovascular risk factors in patients with psoriasis
J Am Acad Dermatol
(2006) - et al.
Obesity and psoriasis: from the Medical Board of the National Psoriasis Foundation
J Am Acad Dermatol
(2010) - et al.
The association of psoriasis and elevated blood lipids in overweight and obese children
J Pediatr
(2011) - et al.
Gastric bypass surgery improves psoriasis
J Am Acad Dermatol
(2011) - et al.
Weight loss improves the response of obese patients with moderate-to-severe chronic plaque psoriasis to low-dose cyclosporine therapy: a randomized, controlled, investigator-blinded clinical trial
Am J Clin Nutr
(2008) - et al.
Bariatric surgery to treat obesity
Semin Nephrol
(2013) - et al.
Gastric bypass surgery: improving psoriasis through a GLP-1-dependent mechanism?
Med Hypotheses
(2011) - et al.
Prevalence and trends in obesity among US adults, 1999-2008
JAMA
(2010) - et al.
Association between tumor necrosis factor inhibitor therapy and myocardial infarction risk in patients with psoriasis
Arch Dermatol
(2012) - et al.
Impact of obesity and smoking on psoriasis presentation and management
Arch Dermatol
(2005)
Increased plasma resistin and decreased omentin levels in Japanese patients with psoriasis
Arch Dermatol Res
Cited by (18)
Skin changes and manifestations associated with the treatment of obesity
2019, Journal of the American Academy of DermatologyCitation Excerpt :These findings, however, are based largely on case reports and retrospective surveys. Most patients reported significant improvements in psoriasis within 1 year.67 In a retrospective survey, 62% noted improvements, 26% no change, and 12% worsening of their psoriasis after undergoing bariatric surgery.64
Impact of obesity and diet on psoriasis
2015, PielDiet in dermatology: Part II. Melanoma, chronic urticaria, and psoriasis
2014, Journal of the American Academy of DermatologyCitation Excerpt :A low calorie diet and weight loss also resulted in improved PASI, Dermatology Life Quality Index (DLQI), and serum lipid levels.170,171 In addition, bariatric surgery–induced weight loss led to the clinical improvement of psoriasis and a decreased need for psoriasis medications.172-174 Weight loss may also improve the efficacy of some psoriasis medications.
Pathogenesis, Molecular Mechanism and Treatment Approaches of Psoriasis: An Update
2024, AIP Conference ProceedingsResolution of Comorbidities Following Bariatric Surgery: Diabetes, Hypertension, Sleep Apnea, and Metabolic Syndrome
2023, Obesity, Bariatric and Metabolic Surgery: A Comprehensive Guide: Second EditionDoes weight loss lead to improvement of dermatological conditions: what is the evidence?
2022, Clinical and Experimental Dermatology
Funding sources: None.
Disclosure: Dr Wu received research funding from Abbott Laboratories, AbbVie, Amgen, Eli Lilly, Merck, and Pfizer, which were not directly related to this study. Mr Sako and Ms Famenini have no conflicts of interest to declare.