Original articleMulticenter Prospective Study of Ulcerated Hemangiomas
Section snippets
Methods
A prospective cohort study was initiated in September 2002 by members of the Hemangioma Investigator Group at 7 U.S. academic pediatric dermatology clinics and 1 international site in Barcelona, Spain. The institutional review board at each participating institution approved the study protocol, and patients’ caregivers provided signed informed consent at the time of enrollment. All investigators were trained in study procedures, data collection, and hemangioma subtype classification by
Results
One thousand ninety-six patients were enrolled over a 13-month period. Enrolled patients had a total of 1960 hemangiomas, and detailed follow-up information was available for 1576 of these. The 384 hemangiomas without detailed follow-up were uncomplicated lesions present on patients with more than 1 hemangioma. Patient characteristics are summarized elsewhere (Haggstrom AN, et al, unpublished data).
The complication of ulceration with or without bleeding was noted in 173 (15.8%) patients. Only
Discussion
Infantile hemangiomas are among the most common of soft tissue tumors in children. Although most lesions are uncomplicated and easily managed by watchful waiting and anticipatory guidance, a significant number may result in diminished quality of life and function- or life-threatening complications.
Ulceration is the most common complication.2, 3, 4, 5 The specific mechanisms causing ulceration are poorly understood. Although historically some believed that ulceration might herald involution,
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Supported by the Dermatology Foundation and the American Skin Association.