Original ArticleNeonatal Benzodiazepines Exposure during Breastfeeding
Section snippets
Methods
A self-referred population of mothers who called the Motherisk Program at the Hospital for Sick Children in Toronto, Ontario, between January 2010 and May 2011 for advice regarding the use of benzodiazepines during lactation were contacted for follow-up. Inclusion criteria consisted of women consenting to the follow-up procedure who were able to be reached, were fluent in English, and used benzodiazepines during breastfeeding. For the sake of confidentiality, calls from lactation consultants,
Results
A total of 296 women contacted the Motherisk program concerning the use of benzodiazepines during lactation between January 1, 2010, and May 31, 2011, and 124 women consented to this investigation. Excluded mothers included 35 who did not take benzodiazepines, 23 who either could not recall details surrounding their benzodiazepine use or refused to participate, and 14 women who did not choose to breastfeed. There were 52 women that could not be reached and 48 telephone numbers that were no
Discussion
The primary objective of the present study was to develop a better understanding of the safety and pharmacodynamics of infant exposure to benzodiazepines during lactation. We detected only 2 cases of sedated infants, and overall, there were no serious adverse drug reactions in participating mothers and children. In both sedated infants, mothers used drugs that are not among the most commonly prescribed in this class: alprazolam and flurazepam combined with clonazepam. There were no significant
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Supported by the Ivey Chair in Molecular Toxicology at the University of Western Ontario. L.K. and P.M. are funded by the Canadian Pharmacogenomics Network for Drug Safety and the Canadian Institutes of Health Research. The authors declare no conflicts of interest.