Asthma, Rhinitis, Other Respiratory DiseasesNormal pregnancy outcomes in a population-based study including 2968 pregnant women exposed to budesonide☆,☆☆
Section snippets
Methods
Information comprising asthma medication during pregnancy and pregnancy outcomes was derived from the Swedish Medical Birth Register, which was founded in 1973. This register contains detailed information on 99% of all births in Sweden (approximately 100,000 per year), including data on newborn infants. The register encompasses case sheet and record data from maternity clinics listing care received during parturition and examination of the newborn infant. This presupposes a similar system of
Study population
The total number of newborn infants in the Swedish Medical Birth Register for 1995 to 1998 was 298,880, after the number of multiple births (n = 4510) and stillbirths (n = 999) were excluded. Information regarding birth weight and length was obtained for 293,948 of these births (study population). Mothers recorded their use of asthma medication during early pregnancy (record form 1). Some 7719 (group A) used asthma medicines other than inhaled or oral glucocorticoids (adrenergics, xanthine
Discussion
Practitioners have been reluctant to prescribe inhaled glucocorticoids to pregnant women because of the general fear of prescribing any medication during pregnancy and because of concerns raised by the labels warning that maternal side effects and adverse perinatal outcomes may result from any type of steroid administration. In addition, some patients are reluctant to take their medication even when prescribed for fear of potential negative effects on the fetus. This may in turn increase the
Acknowledgements
The authors thank Max Köster (Centre for Epidemiology, National Board of Health and Welfare, Stockholm, Sweden) and Jonas Ranstam (Erdeven Medical Statistics Kb, Lund, Sweden) for advice and help with interpretation of the data.
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This study was funded by AstraZeneca R&D, Lund, Sweden.
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Reprint requests: Dr Ensio Norjavaara, AstraZeneca Mölndal, SE-43183 Mölndal, Sweden.