Fetus-Placenta-NewbornUse of cephalosporins during pregnancy and in the presence of congenital abnormalities: A population-based, case-control study☆,☆☆
Section snippets
Material and methods
The Hungarian Congenital Abnormality Registry (HCAR) is a nationally based registry of cases with congenital abnormalities.5 Notification of congenital abnormalities is compulsory for physicians, mainly obstetricians (in Hungary almost all deliveries take place in inpatient obstetric clinics) and pediatricians. Autopsy was obligatory for all infant deaths during the study period, and pathologists sent a copy of the autopsy record to the HCAR in cases of death (stillbirths and infant deaths
Results
The number of total births was 2,146,574 in Hungary during the study period; 38,151 population controls therefore represented 1.8% of Hungarian births. The case group consisted of 22,865 malformed offspring, whereas patient controls with Down syndrome included 812 offspring (Table I). The use of total cephalosporins was slightly higher in the case group (1.35%) than in the population controls (1.15%); this difference is explained mainly by the higher use of cephalexin in the case group. The
Comment
Cephalosporins belong to the β-lactam antibiotics, and they can inhibit the bacterial membrane’s synthesis.1, 2, 3 Cephalosporins were used mainly for the treatment of acute maternal diseases of the urinary tract and respiratory system of pregnant women.
This study compared the use of 7 cephalosporin treatments during pregnancy in the group of cases with congenital abnormalities, their matched healthy population, and the affected patient controls, and the results did not indicate a teratogenic
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2020, Journal of EndodonticsCitation Excerpt :There are conflicting reports on the association between antenatal use of cephalosporins and congenital defects in newborns. Although an earlier study did not find any adverse effect of cephalosporins when used in early pregnancy, subsequent studies have shown an association between cephalosporin use and anorectal atresia and atrial septal defects in newborns59–61. However, these studies were retrospective in nature and relied on maternal recall, and the reported overall absolute risk of malformations was low.
Machine learning on drug-specific data to predict small molecule teratogenicity
2020, Reproductive ToxicologyCitation Excerpt :Beyond these validated associations, we also discovered new structure-teratogenicity relationships that might have application in clarifying cases of suspect toxicity risk in the clinical literature. Indeed, our analysis reveals five motifs that are distinctive among cohorts of molecules identified as "teratogenic" and "non-teratogenic", Both moieties in the "NO" cluster are components of cephalosporins, which include a group of broad-range antibiotics known to be safe for pregnant mothers (class B) [70–73]. Two distinctive functionalities distinguish cephalosporins from other classes of drugs: the presence of an azetidinone group and a dihydrothiazine ring [74].
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2017, International Journal of Women's DermatologyCitation Excerpt :Of the oral antibiotic medications, the beta-lactams are generally considered to be first-line agents. Penicillins and cephalosporins are compatible with pregnancy and show efficacy in the treatment of acne (Czeizel et al., 2001b; Fenner et al., 2008). Amoxicillin is an aminopenicillin and has shown good efficacy in the treatment of patients with acne (Turowski and James, 2007).
Drugs and Environmental Agents in Pregnancy and Lactation: Teratology, Epidemiology
2016, Obstetrics: Normal and Problem PregnanciesUrinary Tract Infection and Bacteriuria in Pregnancy
2015, Urologic Clinics of North AmericaCitation Excerpt :Although resistance is common, these drugs are considered first-line therapy for susceptible bacteria, especially for GBS.28,31,36,43,48 Cephalosporins are also a group of β-lactam antimicrobials with a well-established safety profile in pregnancy.27,28,31,36,43,44,48,49 Susceptible bacteria vary with the different generations.
Anti-infective Agents
2015, Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment: Third Edition
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Supported in part by EuroMap concerted action in the Biomed 2 Workprogramme contract No. BMH4-97-2430 and by Danish Medical Research Council grant No. 9700 677.
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Reprint requests: Andrew E. Czeizel, MD, PhD, Department of Human Genetics, National Center for Epidemiology, Foundation for the Community Control of Hereditary Diseases, Törökvész lejtö 32, Budapest 1026, Hungary.