Journal of the American Academy of Child & Adolescent Psychiatry
SPECIAL SECTION: ADHD COMORBIDITY AND TREATMENT OUTCOMES IN THE MTAClinical Relevance of the Primary Findings of the MTA: Success Rates Based on Severity of ADHD and ODD Symptoms at the End of Treatment
Section snippets
Subjects and Procedures
Methods described elsewhere (Hinshaw et al., 1997) were used to recruit 579 children with ADHD-combined type from geographic locations spread across North America (New York City [Columbia University]; Irvine, CA [UC Irvine]; Pittsburgh [Western Psychiatric Institute and Clinic]; Berkeley, CA [UC Berkeley]; Durham, NC [Duke University]; Queens, NY [Long Island Jewish Medical Center]/ Montreal, Quebec [Montreal Children's Hospital]). Each of these subjects was randomly assigned to one of the four
Continuous Outcome Measures
Descriptive statistics were calculated based on end-of-treatment scores. We used the last observation carried forward (LOCF) technique to replace missing observations at the 14-month assessment. We present information in Table 1 for the three domains from parent SNAP-IV ratings (InattP, H/ImpP, and O/DP) and the three domains from teacher SNAP-IV ratings (InattT, H/ImpT, and O/DT). Similar descriptive statistics were presented in the primary analyses (MTA Cooperative Group, 1999a, Tables 4 and
Three Clarifications of the Primary Findings
The secondary analyses presented here confirm and extend the results of the primary analyses (MTA Cooperative Group, 1999a, MTA Cooperative Group, 1999b). First, these secondary analyses confirm the large ES (Cohen d = 0.59; LOR = 2.79) associated with exposure to the MTA Medication Algorithm (“Comb + MedMgt versus Beh + CC”). The logistic regression analysis revealed that the ES were consistently large at all sites in this study. The clinical impact on “success rate” was substantial: under
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The NIMH Collaborative Multisite Multimodal Treatment Study of Children With Attention-Deficit/Hyperactivity Disorder (MTA) is a cooperative treatment study performed by six independent research teams in collaboration with the staff of the Division of Services and Intervention Research of the NIMH, Rockville, MD, and the Office of Special Education Programs (OSEP) of the U.S. Department of Education (DOE). The NIMH Principal Collaborators are Peter S. Jensen, M.D., L. Eugene Arnold, M.Ed., M.D., John E. Richters, Ph.D., Joanne B. Severe, M.S., Donald Vereen, M.D., and Benedetto Vitiello, M.D. Principal Investigators and Coinvestigators from the six sites are as follows: University of California at Berkeley/San Francisco (UO1 MH50461): Stephen P. Hinshaw, Ph.D., Glen R. Elliott, M.D., Ph.D.; Duke University (UO1 MH50447): C. Keith Conners, Ph.D., Karen C. Wells, Ph.D., John S. March, M.D., M.P.H.; University of California at Irvine/Los Angeles (UO1 MH50440): James M. Swanson, Ph.D., Dennis P. Cantwell, M.D., Timothy Wigal, Ph.D.; Long Island Jewish Medical Center/Montreal Children's Hospital (UO1 MH50453): Howard B. Abikoff, Ph.D., Lily Hechtman, M.D.; New York State Psychiatric Institute/Columbia University/Mount Sinai Medical Center (UO1 MH50454): Laurence L. Greenhill, M.D., Jeffrey H. Newcorn, M.D.; University of Pittsburgh (UO1 MH50467): William E. Pelham, Ph.D., Betsy Hoza, Ph.D. Helena C. Kraemer, Ph.D. (Stanford University) is statistical and design consultant. The OSEP/DOE Principal Collaborator is Ellen Schiller, Ph.D.